Now showing items 11-20 of 124
Acetylcholine‐synthesizing macrophages in subcutaneous fat are regulated by β2‐adrenergic signaling
(Wiley Periodicals, Inc., 2021-12-15)
Non‐neuronal cholinergic signaling, mediated by acetylcholine, plays important roles in physiological processes including inflammation and immunity. Our group first discovered evidence of non‐neuronal cholinergic circuitry ...
Functional coordination of non‐myocytes plays a key role in adult zebrafish heart regeneration
(Wiley Periodicals, Inc.University of Oregon Press, 2021-11-04)
Cardiac regeneration occurs primarily through proliferation of existing cardiomyocytes, but also involves complex interactions between distinct cardiac cell types including non‐cardiomyocytes (non‐CMs). However, the ...
Distinct heterochromatin‐like domains promote transcriptional memory and silence parasitic genetic elements in bacteria
(Academic PressWiley Periodicals, Inc., 2022-02-01)
There is increasing evidence that prokaryotes maintain chromosome structure, which in turn impacts gene expression. We recently characterized densely occupied, multi‐kilobase regions in the E. coli genome that are ...
Safety and efficacy of polatuzumab vedotin + obinutuzumab for relapsed/refractory non‐Hodgkin lymphomas: A phase IB/II study
(John Wiley & Sons, Inc., 2022-01-01)
Pharmacological inhibition of Carbonic Anhydrase IX and XII to enhance targeting of acute myeloid leukaemia cells under hypoxic conditions
(Wiley Periodicals, Inc., 2021-12)
Acute myeloid leukaemia (AML) is an aggressive form of blood cancer that carries a dismal prognosis. Several studies suggest that the poor outcome is due to a small fraction of leukaemic cells that elude treatment and ...
Freeze‐dried platelets are a promising alternative in bleeding thrombocytopenic patients with hematological malignancies
(John Wiley & Sons, Inc., 2022-03-01)
Thrombosomes are trehalose‐stabilized, freeze‐dried group O platelets with a 3‐year shelf life. They can be stockpiled, rapidly reconstituted, and infused regardless of the recipient’s blood type. Thrombosomes thus represent ...
Sarcolemma wounding activates dynamin‐dependent endocytosis in striated muscle
(Wiley Periodicals, Inc., 2021-01)
Human induced pluripotent stem cell‐derived lung organoids in an ex vivo model of the congenital diaphragmatic hernia fetal lung
(John Wiley & Sons, Inc., 2021-01)
Three‐dimensional lung organoids (LOs) derived from pluripotent stem cells have the potential to enhance our understanding of disease mechanisms and to enable novel therapeutic approaches in neonates with pulmonary disorders. ...
Organismal benefits of transcription speed control at gene boundaries
(Wiley Periodicals, Inc., 2020-04-03)
RNA polymerase II (RNAPII) transcription is crucial for gene expression. RNAPII density peaks at gene boundaries, associating these key regions for gene expression control with limited RNAPII movement. The connections ...