Now showing items 21-30 of 124
Clonal hematopoiesis associated with epigenetic aging and clinical outcomes
(Springer, New YorkWiley Periodicals, Inc., 2021-06)
Clonal hematopoiesis of indeterminate potential (CHIP) is a common precursor state for blood cancers that most frequently occurs due to mutations in the DNA‐methylation modifying enzymes DNMT3A or TET2. We used DNA‐methylation ...
Cap‐independent translation: A shared mechanism for lifespan extension by rapamycin, acarbose, and 17α‐estradiol
(Wiley Periodicals, Inc., 2021-05)
We hypothesized that rapamycin (Rapa), acarbose (ACA), which both increase mouse lifespan, and 17α‐estradiol, which increases lifespan in males (17aE2) all share common intracellular signaling pathways with long‐lived Snell ...
17- a- estradiol late in life extends lifespan in aging UM- HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex
(Wiley Periodicals, Inc., 2021-05)
In genetically heterogeneous mice produced by the CByB6F1 x C3D2F1 cross, the - non- feminizing- estrogen, 17- α- estradiol (17aE2), extended median male lifespan by 19% (p < 0.0001, log- rank test) and 11% ...
Urine stem cells are equipped to provide B cell survival signals
(John Wiley & Sons, Inc., 2021-06)
The interplay between mesenchymal stem cells (MSCs) and immune cells has been studied for MSCs isolated from different tissues. However, the immunomodulatory capacity of urine stem cells (USCs) has not been adequately ...
Inflammation and matrix metalloproteinase 9 (Mmp- 9) regulate photoreceptor regeneration in adult zebrafish
(John Wiley & Sons, Inc., 2020-07)
Brain injury activates complex inflammatory signals in dying neurons, surviving neurons, and glia. Here, we establish that inflammation regulates the regeneration of photoreceptors in the zebrafish retina and determine the ...
Tricuspid regurgitation velocity and other biomarkers of mortality in children, adolescents and young adults with sickle cell disease in the United States: The PUSH study
(John Wiley & Sons, Inc., 2020-07)
In the US, mortality in sickle cell disease (SCD) increases after age 18- 20- years. Biomarkers of mortality risk can identify patients who need intensive follow- up and early or novel interventions. We prospectively ...
Safety and activity of ibrutinib in combination with durvalumab in patients with relapsed or refractory follicular lymphoma or diffuse large B‐cell lymphoma
(John Wiley & Sons, Inc., 2020-01)
This phase 1b/2, multicenter, open‐label study evaluated ibrutinib plus durvalumab in relapsed/refractory follicular lymphoma (FL) or diffuse large B‐cell lymphoma (DLBCL). Patients were treated with once‐daily ibrutinib ...
Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging‐related kidney injury
(Wiley Periodicals, Inc., 2021-07)
The mechanism of kidney injury in aging are not well understood. In order to identify hitherto unknown pathways of aging‐related kidney injury, we performed RNA‐Seq on kidney extracts of young and aged mice. Expression of ...
Protonation status and control mechanism of flavin–oxygen intermediates in the reaction of bacterial luciferase
(Wiley Periodicals, Inc.World Scientific Publishing Co. Pte. Ltd., 2021-05)
Metabolipidomic profiling reveals an age- related deficiency of skeletal muscle pro- resolving mediators that contributes to maladaptive tissue remodeling
(Wiley Periodicals, Inc., 2021-06)
Specialized pro- resolving mediators actively limit inflammation and support tissue regeneration, but their role in age- related muscle dysfunction has not been explored. We profiled the mediator lipidome of aging muscle ...