Now showing items 11-20 of 43
Phosphoenolpyruvate Carboxykinase (GTP): Characterization of the Human PCK1 Gene and Localization Distal to MODY on Chromosome 20
(Elsevier, 1993-06)
The human PCK1 gene encoding phosphoenolpyruvate carboxykinase (GTP) (PEPCK) was isolated and sequenced. There is 91% amino acid sequence identity (567/622 residues) between the human and the rat proteins, with conservation ...
Continued search for the cellular signals that regulate regeneration of dopaminergic neurons in goldfish retina
(Elsevier, 1993-12-17)
Intraocular injections of low doses (0.7-1.4 mM estimated intraocular concentration) of 6-hydroxydopamine (6OHDA) selectively destroy dopaminergic neurons in the inner nuclear layer (INL) of goldfish retina, and they never ...
A test of the equal-environment assumption in twin studies of psychiatric illness
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1993-01)
The traditional twin method is predicated on the equal-environment assumption (EEA)—that monozygotic (MZ) and dizygotic (DZ) twins are equally correlated in their exposure to environmental events of etiologic importance ...
Quantitative structure-activity relationships for the mutagenicity of propylene oxides with Salmonella
(Elsevier, 1993-04)
A quantitative structure-activity relationship approach was used to investigate the mutagenicity of a series of seventeen-monosubstituted propylene oxides in Salmonella typhimurium strains TA100 and TA1535. Mutagenicity ...
Genetic Mapping and Evaluation of Candidate Genes for Spasmodic, a Neurological Mouse Mutation with Abnormal Startle Response
(Elsevier, 1993-08)
Spasmodic (spd) is a recessive mouse mutation characterized by a prolonged righting reflex, fine motor tremor, leg clasping, and stiffness. Using an intersubspecific backcross that segregates spd, we placed spd on Chr 11 ...
Retroviruses: delivery vehicle to the liver
(Elsevier, 1993-02)
Liver-directed gene therapy holds great promise for the treatment of inherited metabolic disease. Two strategies have emerged. Ex vivo gene therapy involves the transplantation of autologous hepatocytes transduced with ...
Effect of hydrogen peroxide on the biodegradation of PCBs in anaerobically dechlorinated river sediments
(Kluwer Academic Publishers; Springer Science+Business Media, 1993-12)
The ability to initiate aerobic conditions in dechlorinated anaerobic sediments was tested using hydrogen peroxide as an oxygenation agent. Hydrogen peroxide additions to the sediment induced aerobic polychlorinated biphenyl ...