Now showing items 31-40 of 43
Multicolor FISH Mapping with Alu-PCR-Amplified YAC Clone DNA Determines the Order of Markers in the BRCA1 Region on Chromosome 17q12-q21
(Elsevier, 1993-09)
A gene designated BRCA1, implicated in the susceptibility to early-onset familial breast cancer, has recently been localized to chromosome 17q12-q21. To date, the order of DNA markers mapped within this region has been ...
Testing hypotheses about direction of causation using cross-sectional family data
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1993-01)
We review the conditions under which cross-sectional family data (e.g., data on twin pairs or adoptees and their adoptive and biological relatives) are informative about direction of causation. When two correlated traits ...
Fibrillin genes map to regions of conserved mouse/human syntenyon mouse chromosomes 2 and 18
(Elsevier, 1993-12)
Fibrillin proteins are major structural components of the 10-nm microfibrils found in elastic and nonelastic connective tissues. Previous studies have mapped the human genes for two fibrillins to chromosome bands 15q21 ...
Chromosomal aberrations in mouse lymphocytes exposed in vivo and in vitro to aliphatic epoxides
(Elsevier, 1993-03)
Mouse lymphocytes in vivo or in vitro were exposed for 24 h to 4 aliphatic epoxides, glycidyl 1-naphthyl ether, glycidyl 4-nitrophenyl ether, 1-naphthylpropylene oxide and trichloropropylene oxide (TCPO), and tested for ...
ortho-Substituent effects on the in vitro and in vivo genotoxicity of benzidine derivatives
(Elsevier, 1993-09)
Benzidine and its 3,3'-diamino, 3,3'-dimethyl, 3,3'-dimethoxy, 3,3'-difluoro, 3,3'-dichloro, 3,3'-dibromo, 3,3'-dicarbomethoxy and 3,3'-dinitro derivatives together with 2-nitrobenzidine and 3-nitrobenzidine were compared ...
The genotoxicity of enantiomeric aliphatic epoxides
(Elsevier, 1993-01)
The (R)- and (S)-optical isomers of 9 epoxides, benzyloxymethyloxirane, epichlorohydrin, glycidol, glycidyl 3-nitrobenzenesulfonate, glycidyl 4-nitrobenzoate, glycidyl tosylate, styrene oxide, glycidyl 1-naphthyl ether and ...
The Genes Encoding Gonadal and Nongonadal Forms of 3[beta]-Hydroxysteroid Dehydrogenase/[Delta]5-[Delta]4 Isomerase Are Closely Linked on Mouse Chromosome 3
(Elsevier, 1993-04)
The biosynthesis of steroid hormones in the gonads and adrenal glands requires the activities of the enzyme 3[beta]-hydroxysteroid dehydrogenase/isomerase (3[beta]HSD) which catalyzes the NAD+-dependent dehydrogenation and ...
Distribution of the admixture test for the detection of linkage under heterogeneity
(Wiley Subscription Services, Inc., A Wiley Company, 1993)
The admixture test for the detection of linkage under heterogeneity is considered. We show that the null distribution of this test statistic has half its weight concentrated on zero and the other half on a complicated ...
Characterization of the Left 4 kb of Conjugative Transposon Tn916: Determinants Involved in Excision
(Elsevier, 1993-11)
The rate-limiting step in movement of the conjugative transposon Tn916, originally identified in Enterococcus faecalis, is believed to be an excision event that generates a non-replicative circular intermediate. When present ...
Diurnal Regulation of Glucocorticoid Receptor and Mineralocorticoid Receptor mRNAs in Rat Hippocampus
(Elsevier, 1993-04)
The present studies were undertaken to determine whether hippocampal glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) biosynthesis, as inferred from mRNA expression, exhibit diurnal patterns of activation ...