Now showing items 51-60 of 121
Dose‐dependent proteomic analysis of glioblastoma cancer stem cells upon treatment with γ‐secretase inhibitor
(WILEY‐VCH Verlag, 2011-12)
Notch signaling has been demonstrated to have a central role in glioblastoma (GBM) cancer stem cells (CSCs) and we have demonstrated recently that Notch pathway blockade by γ‐secretase inhibitor (GSI) depletes GBM CSCs and ...
How microbial proteomics got started
(WILEY‐VCH Verlag, 2011-08)
Publication in 1975 by Patrick O'Farrell of a procedure to separate the proteins of Escherichia coli in a two‐dimensional array on polyacrylamide gels marked the birth of the field now called proteomics. Although O'Farrell's ...
Changes in the rat heart proteome induced by exercise training: Increased abundance of heat shock protein hsp20
(WILEY-VCH Verlag, 2006-05)
Chronic exercise training elicits adaptations in the heart that improve pump function and confer cardioprotection. To identify molecular mechanisms by which exercise training stimulates this favorable phenotype, a proteomic ...
Proteome-wide changes induced by the Hsp90 inhibitor, geldanamycin in anaplastic large cell lymphoma cells
(WILEY-VCH Verlag, 2007-08)
The molecular chaperone heat shock protein 90 (Hsp90) affects the function of many oncogenic signaling proteins including nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) expressed in anaplastic large cell lymphoma (ALCL). ...
Proteomic profiling identifies breast tumor metastasis-associated factors in an isogenic model
(WILEY-VCH Verlag, 2007-01)
A combination of LC and MS was applied to an isogenic breast tumor metastasis model to identify proteins associated with a cellular phenotype. Chromatofocusing followed by nonporous-RP-HPLC/ESI-TOF MS was applied to cell ...
Development of selected reaction monitoring-MS methodology to measure peptide biomarkers in prostate cancer
(WILEY-VCH Verlag, 2010-10)
Prostate cancer is a leading cause of cancer-related death. The current modality of diagnosis, the measurement of serum PSA, not only suffers from lack of specificity, but does not distinguish clinical cases in which current ...
A NMR Investigation of Structure and Allostery in the Hsp70 Chaperone System.
(2010)
The Hsp70 Chaperone system is a complex molecular machine composed of proteins. It is responsible for assisting in protein folding/refolding/processing and transport. Hsp70 proteins have been historically associated with ...
Synthesis of p-nitrophenyl 2-O-[alpha]--mannopyranosyl-[alpha]--mannopyranoside and p-nitrophenyl 6-O-[alpha]--mannopyranosyl-[alpha]--mannopyranoside
(Elsevier, 1979-12)
Crystalline 2-O-[alpha]--mannopyranosyl-[beta]--mannopyranose octaacetate was synthesized by condensation of tetra-O-acetyl-[alpha]--mannopyranosyl bromide (3) with 1,3,4,6-tetra-O-acetyl-[beta]--mannopyranose. ...
Gas-liquid chromatography of carbohydrate derivatives: the separation and quantitative determination of synthetic and naturally occurring glycosyl derivatives of amino acids
(Elsevier, 1972-05)
A gas-liquid chromatographic separation of the trimethylsilyl derivatives of several synthetic and naturally occurring glycosyl derivatives of amino acids is described. This technique may be used for the qualitative and ...
Label‐free profiling of white adipose tissue of rats exhibiting high or low levels of intrinsic exercise capacity
(Wiley Periodicals, Inc., 2015-07)