Now showing items 4181-4190 of 4208
Palmitoylation Plays a Role in Targeting Vac8p to Specific Membrane Subdomains
(Blackwell Publishing Ltd, 2006-10)
Sepsis, complement and the dysregulated inflammatory response
(Blackwell Publishing Ltd, 2009-10)
• Introduction - Models of sepsis - Evidence for complement activation in sepsis - Protective effects of C5a generated in limited amounts - Sepsis-induced changes in signalling cascades - Divergent effects on ...
Thymidine block does not synchronize L1210 mouse leukaemic cells: implications for cell cycle control, cell cycle analysis and whole-culture synchronization
(Blackwell Publishing Ltd, 2008-02)
It has been predicted that whole-culture methods of synchronization cannot synchronize cells. We have tested whether thymidine block, one type of whole-culture synchronization, can synchronize L1210 cells. We demonstrate ...
Treponema denticola increases MMP‐2 expression and activation in the periodontium via reversible DNA and histone modifications
(Wiley Periodicals, Inc., 2018-04)
Host‐derived matrix metalloproteinases (MMPs) and bacterial proteases mediate destruction of extracellular matrices and supporting alveolar bone in periodontitis. The Treponema denticola dentilisin protease induces MMP‐2 ...
Glycine supplementation extends lifespan of male and female mice
(Wiley Periodicals, Inc., 2019-06)
Diets low in methionine extend lifespan of rodents, though through unknown mechanisms. Glycine can mitigate methionine toxicity, and a small prior study has suggested that supplemental glycine could extend lifespan of ...
let‐7‐repressesed S hc translation delays replicative senescence
(Wiley Periodicals, Inc., 2014-02)
Cutaneous T‐cell lymphomas: 2021 update on diagnosis, risk‐stratification, and management
(John Wiley & Sons, Inc., 2021-10-01)
Disease overviewCutaneous T‐cell lymphomas are a heterogenous group of T‐cell neoplasms involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS).DiagnosisThe diagnosis ...
Neuroprotective effects of Canagliflozin: Lessons from aged genetically diverse UM-HET3 mice
(Wiley Periodicals, Inc., 2022-07)
The aging brain is characterized by progressive increases in neuroinflammation and central insulin resistance, which contribute to neurodegenerative diseases and cognitive impairment. Recently, the Interventions Testing ...
Decitabine and vorinostat with FLAG chemotherapy in pediatric relapsed/refractory AML: Report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium
(John Wiley & Sons, Inc., 2022-05)
Survival outcomes for relapsed/refractory pediatric acute myeloid leukemia (R/R AML) remain dismal. Epigenetic changes can result in gene expression alterations which are thought to contribute to both leukemogenesis and ...