Now showing items 4191-4200 of 4208
Cap-independent translation of GPLD1 enhances markers of brain health in long-lived mutant and drug-treated mice
(Wiley Periodicals, Inc., 2022-09)
Glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1) hydrolyzes inositol phosphate linkages in proteins anchored to the cell membrane. Mice overexpressing GPLD1 show enhanced neurogenesis and cognition. Snell ...
Dual‐detection approach for a charge variant analysis of monoclonal antibody combination products using imaged capillary isoelectric focusing
(Wiley Periodicals, Inc.Springer Science+Business Media, 2022-09)
The clinical benefits of treatments with a combination of two or more therapeutic monoclonal antibodies (mAbs) have emerged in recent years. Imaged capillary isoelectric focusing is a frequently used technology in the ...
Cochlear Neurotrophin-3 overexpression at mid-life prevents age-related inner hair cell synaptopathy and slows age-related hearing loss
(Wiley Periodicals, Inc.Elsevier, 2022-10)
Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This progressive pathology often has psychological and medical comorbidities, including social isolation, depression, and cognitive ...
Oral biofilm dysbiosis during experimental periodontitis
(Wiley Periodicals, Inc., 2022-12)
ObjectivesWe have previously characterized the main osteoimmunological events that occur during ligature periodontitis. This study aims to determine the polymicrobial community shifts that occur during disease developmen ...
Mimicking partial to total placental insufficiency in a rabbit model of cerebral palsy
(Springer International PublishingWiley Periodicals, Inc., 2022-12)
All placental abruptions begin as partial abruptions, which sometimes manifest as fetal bradycardia. The progression from partial to total abruption was mimicked by a new rabbit model of placental insufficiency, and we ...
Mechanisms of skeletal muscle repair and regeneration in health and disease
(Wiley Periodicals, Inc., 2022-11)
Cutaneous T-cell lymphomas: 2023 update on diagnosis, risk-stratification, and management
(John Wiley & Sons, Inc., 2023-01)
Disease OverviewCutaneous T-cell lymphomas are a heterogenous group of T-cell neoplasms involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS).DiagnosisThe diagnosis ...
Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms
(Wiley Periodicals, Inc., 2023-01)
It is challenging to study regulatory genetic variants as gene expression is affected by both genetic polymorphisms and non-genetic regulators. The mRNA allele-specific expression (ASE) assay has been increasingly used for ...
Lip service: Histological phenotypes correlate with diet and feeding ecology in herbivorous pacus
(John Wiley & Sons, Inc., 2023-02)
Complex prey processing requires the repositioning of food between the teeth, as modulated by a soft tissue appendage like a tongue or lips. In this study, we trace the evolution of lips and ligaments, which are used during ...