Now showing items 151-160 of 164
Biophysical Approaches to Target Protein-Protein Interactions of Epigenetic Complexes by Small-Molecule Inhibitors
(2019)
Innumerable biological systems rely on Protein-Protein Interactions (PPIs) to govern basal physiological processes. Deregulation of PPIs is implicated in various human diseases, and PPIs have thus been frequently promoted ...
Advances in Coarse-grained Models for Protein Folding and Protein-protein Interactions
(2019)
Almost all biological functions rely on the dynamics of proteins. Protein folding and protein-protein interactions are the two most fundamental problems of protein dynamics. Molecular dynamics (MD) simulation is a powerful ...
Computational Methods for Characterizing Post-translational and Chemical Modifications Found in Open Searches
(2022)
Post-translational modifications (PTMs) govern many processes within cells and understanding their function is critical to both the basic and biomedical sciences. However, identifying modified peptides, particularly ...
Development of a Chemoproteomic Approach to Study Kinase-Substrate Interactions and the Discovery of CDK4 as a 4E-BP1 Kinase
(2019)
An instrumental aspect of cancer progression is the acquired deregulation of the cellular processes that regulate growth and proliferation. Most of these processes are, at some level, controlled by a kinase-catalyzed change ...
Biological Applications of Surfaces with Extreme Wettabilities
(2019)
Surfaces with extreme wettabilities have become an increasingly popular topic due to their wide range of applications – from simply keeping dirt off clothing to oil-water separation in the event of an oil spill. In particular, ...
Structural Studies and Pharmacological Targeting of Protein Kinases in Obesity and Heart Disease
(2018)
Adrenergic receptors (AR) are G protein-coupled receptors (GPCRs) responsible for regulating physiological processes including the fight-or-flight response, muscle contraction, blood flow, and energy release. Numerous ...
Inhibition of Nucleotide and One-Carbon Metabolism for the Treatment of Cancer
(2021)
Metabolic reprogramming in cancer was first described in the early to mid-1900s and later labeled as a hallmark. Rapidly proliferating cells require sufficient concentrations of nucleotides and other biomass precursor ...
Understanding Pre-mRNA Dynamics in Single Spliceosome Complexes.
(2013)
The spliceosome is a large RNA-protein complex that catalyzes pre-mRNA splicing by removing sequences called introns and joining of the remaining sequences, called exons, to produce a mature mRNA. Despite over a quarter ...
Super-resolution Imaging of DNA Replisome Architecture and Dynamics in Live Bacillus Subtilis
(2018)
DNA replication happens in all living organisms and assures that the genome is accurately copied and maintained. The replisome is the molecular machine in cells that replicates DNA, and this protein assembly includes DNA ...
Specialized Metabolites and Related Biosynthetic Enzymes in Tomato Glandular Trichomes: Defining Biological Functions of Specific Gland Types.
(2011)
Trichomes are tiny appendages that grow out from the surfaces of leaves, stems, flowers, and other above-ground parts of many plants. They contribute to important biological functions such as determent of herbivores, ...