Now showing items 911-920 of 950
The Role of Corticotropin-Releasing Hormone-Binding Protein in Binge Drinking and Alcohol Dependence
(2017)
Alcoholism is a chronic and progressive disorder characterized by periods of excessive drinking, withdrawal and abstinence, and eventual relapse. Both genetic and environmental factors contribute to the development of ...
Neurotrophic Factor Signaling Mechanisms Underlying the Development of Peripheral Neural Circuits
(2018)
The first discovery of a growth-regulating signaling molecule was more than 65 years ago, when the work of Rita Levi-Montalcini, Viktor Hamburger, and Stanley Cohen led to the identification and purification of nerve growth ...
Sexual Deprivation, Emotion, and Longevity: Neuropeptidergic Regulation of Aging in Drosophila
(2018)
While researchers often focus on the brain as a victim of aging via neurodegenerative diseases, recent work has demonstrated that the aging process is regulated by neural mechanisms. Thus, we asked which mechanisms and ...
The Oxidative Modification of Mitochondrial Proteins in 1,3-Dinitrobenzene Induced Neurotoxicity.
(2009)
1,3-DNB has widespread use in industry and the military as a chemical intermediate in the development of various plastics, dyes, and explosives. As a result, the production and improper disposal of various DNB-containing ...
The Effects of REM Sleep Deprivation on Spatial and Reversal Learning.
(2010)
Typically, when REM sleep restriction is applied during learning (concurrent learning) performance is impaired. It is unclear how REM sleep restriction can alter other forms of spatial learning (e.g. reversal learning). ...
Role of Central Amygdala Opioids in Incentive Motivation: Translating Learning into Focused and Amplified 'Wanting'.
(2009)
Wanting a reward like food is different from liking it, and the brain processes these sensations separately. Components of the limbic system mediate both, and here I examined how different neurochemical signals (opioids ...
Receptor Regulation of Volume-Sensitive Osmolyte Efflux from Neural Cells.
(2007)
Cell volume regulation is a homeostatic imperative in the brain due to the restrictions of the skull. To counteract an osmolarity disturbance and restore normal cell volume, neural cells initiate volume regulatory mechanism ...
Who moved my protein? Mechanisms of Epileptogenesis due to Mutations of Voltage-Gated Sodium Channel SCN1B.
(2010)
Voltage-gated sodium channels (VGSCs) play a role in the generation of action potentials in excitable cells, including neurons. VGSCs contain one pore-forming α subunit, one non-covalently linked (β1 or β3) and one covalently ...
Photoperiodic Properties of Circadian Rhythm in Rat.
(2011)
Animals have intrinsic circadian periods of around 24 hours. In order to synchronize to the 24-hour day, circadian rhythms entrain to photic time cues and establish a consistent daily rhythm. The maintenance of a stable ...
The Effects of Cortisol on Emotion
(2009)
Release of the hormone cortisol is normally tightly regulated. However, when regulation fails and cortisol is hypersecreted (as in Cushing’s disease), significant emotional changes occur, including depression, raising the ...