Now showing items 921-930 of 950
Longitudinal Behavioral Evaluation of a Knock-In Mouse Model of Huntington Disease and Mechanisms of Pathogenesis.
(2008)
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by expanded CAG repeat/polyglutamine repeats within the huntingtin locus resulting in a pathogenic huntingtin protein (htt). Early and ...
The Neurogenic Niche and Injury-Induced Neurogenesis.
(2008)
Neurogenesis persists in the forebrain subventricular zone (SVZ) where neural stem cells (NSCs) reside in a specific niche. Stroke stimulates SVZ NSCs, which offer reparative potential, but few new neurons survive long-term. ...
Task-Dependence of Spatial Sensitivity in Areas A1, DZ and PAF of Cat Auditory Cortex.
(2010)
Auditory cortex is essential for normal sound localization behavior. Reversible inactivation of primary auditory area (A1), dorsal zone (DZ) or posterior auditory field (PAF) in cats produces varying types and degrees of ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
The Speed of Intravenous Cocaine Delivery Alters its Effect on the Brain and Drug-Taking Behavior: Implications for Addiction Liability.
(2010)
Cocaine addiction in humans is a severe health and social problem. Therefore, understanding how casual use transforms into addiction is critical. One of the many factors that can facilitate addiction is how rapidly drugs ...
Role of Noradrenergic Signaling in the Basolateral Amygdala in Habituation to Repeated Stress.
(2009)
The hypothalamic-pituitary-adrenal (HPA) axis is an important stress-responsive system, but overactivity of the HPA axis can be detrimental to the physiological and psychological health of the organism. HPA activity ...
The role of Neurofibromatosis Type 1 in Schwann Cell development and tumor formation and the influence of steroid hormones.
(2007)
The Neurofibromatosis Type 1 (NF1) gene functions as a tumor suppressor gene. One known NF1 function is to turn off the p21ras pathway by accelerating Ras hydrolyzation of active rasGTP to inactive rasGDP. Loss of neurofibromin ...
Exploration and Exploitation of Action Selection in the Motor Cortex and Basal Ganglia.
(2010)
The basal ganglia (BG) have been proposed as a possible neural substrate for action selection in the vertebrate brain. In this thesis, I have focused on determining the role of BG circuits in selection of well-trained ...
Interplay Between Default-Mode and Task-Positive Networks: Functional Characterization of the Brain's Large-Scale Neural Systems.
(2010)
Recent work has demonstrated that the human brain is functionally organized into distinct large-scale networks, with particular attention focused on the default-mode network (DMN) and the anti-correlated “task-positive” ...
Coordination of Eye and Head Movements in Cavia Porcellus.
(2011)
The present work provides novel insights into the coordination of vestibular reflexes in the head-unrestrained guinea pig. Eye and head movements were recorded during passive whole body rotations and active head movements. ...