Now showing items 11-20 of 40
3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") and its stereoisomers as reinforcers in rhesus monkeys: serontonergic involvement
(Springer-Verlag, 2002-06)
Rationale: The reinforcing effects of MDMA and its enantiomers have not been extensively characterized in laboratory animals. Objectives: To investigate whether MDMA and its stereoisomers would be self-administered ...
Observing responses maintained by stimuli associated with cocaine or remifentanil reinforcement in rhesus monkeys
(Springer-Verlag, 2002-10)
Abstract
Topiramate attenuates exaggerated acoustic startle in an animal model of PTSD
(Springer-Verlag, 2004-03)
Exaggerated acoustic startle is a prominent symptom of post-traumatic stress disorder (PTSD); however, its physiological basis is not well understood, and there are few available treatments. Neurobiological research has ...
The ascending limb of the cocaine dose-response curve for reinforcing effect in rhesus monkeys
(Springer-Verlag, 2003-02)
Rationale. To date, the literature on the intravenous self-administration of cocaine by laboratory animals lacks a compelling demonstration of an ascending limb to the dose-response function. It has been argued that previous ...
Hallucinogen-like actions of 2,5-dimethoxy-4-( n )-propylthiophenethylamine (2C-T-7) in mice and rats
(Springer-Verlag, 2005-09)
Few studies have examined the effects of 2,5-dimethoxy-4-( n )-propylthiophenethylamine (2C-T-7) in vivo.
Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice
(Springer-Verlag, 2004-05)
No selective antagonists for the effects of MDMA have yet been identified. The structurally-similar, naturally-occurring plant alkaloid nantenine (9,10-methylenedioxy-1,2 dimethoxyaporphine) may represent such a compound.
A role for the prefrontal cortex in stress- and cocaine-induced reinstatement of cocaine seeking in rats
(Springer-Verlag; Springer-Verlag, 2003-07)
It is well established that stress induces reinstatement of drug seeking in an animal model of relapse. Here we studied the role of the medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC) in foot-shock stress-induced ...
Summary of a National Institute of Mental Health workshop: developing animal models of anxiety disorders
(Springer-Verlag, 2001-10)
Rationale: There exists a wide range of animal models and measures designed to assess anxiety or fearfulness. However, the relationship between these models and clinical anxiety symptoms and syndromes is unclear. The ...
The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats
(Springer-Verlag, 2005-07)
Exposure to extreme stress has been suggested to produce long-term, detrimental alterations in the hypothalamic–pituitary–adrenal (HPA) axis leading to the development of mental disorders such as depression. Therefore, ...
Differential effects of nicotine on alcohol consumption in men and women
(Springer-Verlag, 2006-05)
Nicotine and alcohol are frequently co-used, suggesting that use of one drug may facilitate use of the other. Furthermore, because men and women differ in their responses to both drugs, it is possible that men and women ...