Now showing items 351-360 of 409
Neural Representation of Hedonic Tastes in the Ventral Pallidum.
(2014)
The overall goal of this thesis was to investigate how the ventral pallidum tracks experimentally-induced changes in the hedonic value of tastes. Taste reactions allows us to measure how ‘liked’ or ‘disliked’ a taste is ...
Form and Function in the Scn1b-null Cerebellar Cortex: Implications for Epileptic Encephalopathy
(2017)
Dravet syndrome is a catastrophic, pediatric epileptic encephalopathy which is caused by genetic mutations is voltage-gated Na+ channel (VGSC) subunit genes. In addition to severe seizures, patients present with cognitive ...
Structure and Dynamics of Emotional Experience in Depression.
(2012)
Human emotional experience is extremely complex and dynamic. Multiple factors
contribute to the ever changing subjective experience of emotion. Exteroceptive
information from our senses, interoceptive information from ...
Cognitive Contributions to Motor Learning
(2018)
Transcranial direct current stimulation (tDCS) can facilitate motor learning. However, the tDCS literature scarcely addresses whether stimulation to prefrontal brain regions affects motor learning, whether chunking together ...
An Examination of Brain Network Organization and the Analgesic Mechanisms of a Non-Pharmacological Treatment in Chronic Centralized Pain
(2017)
Chronic pain is a global public health challenge, affecting nearly one third of adults worldwide. Current treatments are inadequate, especially since some of the mainstay therapies (e.g. opioids, NSAIDs) are often ineffective ...
The Contribution of Calcium-Activated Potassium Channel Dysfunction to Altered Purkinje Neuron Membrane Excitability in Spinocerebellar Ataxia
(2018)
Spinocerebellar ataxias (SCA) are a family of dominantly-inherited neurodegenerative disorders which affect movement and coordination. Patients experience the shared features of cerebellar ataxia, characterized by uncoordinated ...
Dopaminergic Regulation of Pair Bonding in the Socially Monogamous Prairie Vole
(2017)
The development and maintenance of pair bonds in the socially monogamous prairie vole is regulated in part by the mesolimbic dopamine system. My dissertation work investigates dopamine signaling mechanisms involved in the ...
Brain Tissue Response in Neurochemical Sampling: Microdialysis and Low-Flow Push-Pull Perfusion.
(2013)
Neurochemical sensing via sampling probes is essential for deciphering neuronal communication and enabling technologies to alleviate brain disorders such as mental illness and Parkinson’s. The brain tissue response associated ...
Investigating the Role of Protein Kinase C Inhibitors in Amphetamine-Mediated Behaviors
(2019)
Amphetamines (AMPH) are among the most widely misused drugs in the United States and worldwide. Currently, there are no pharmacological interventions for amphetamine-use disorder. A close examination of mechanism of action ...
Toward Understanding the Polyglutamine Disorder Spinocerebellar Ataxia Type 3 Using Mouse Models of Disease
(2017)
The polyglutamine (polyQ) diseases, including Spinocerebellar Ataxia type 3 (SCA3), are inherited neurodegenerative diseases caused by glutamine-encoding CAG expansions in disease genes. All polyQ diseases exhibit accumulation ...