Now showing items 361-370 of 409
In Vitro and In Vivo Testing of Ultra-Small Gold Nanoparticles as a Novel Drug Delivery Platform for Enhancing the Brain Penetration and Receptor Binding Affiinity of Central Nervous System Drugs.
(2013)
The endothelial cells of brain capillaries form the so-called blood brain barrier (BBB) which protects the central nervous system (CNS) from the entry of neurotoxins and blood components. Consequently, more than 98% of ...
Molecular Mechanisms of Immune-Mediated Axon Regeneration in the Injured Central Nervous System.
(2015)
In the injured adult mammalian central nervous system (CNS), severed axons fail to undergo spontaneous regeneration, leading to permanent neurological deficits, such as paralysis following spinal cord injury, and cognitive ...
Predictors of Off-Diagonal Binge Drinking and Marijuana Use Trajectory Groups Through the Transition to Adulthood.
(2016)
Binge drinking and marijuana use are serious health risk behaviors. Early onset, chronic users tend to receive the majority of clinical and empirical attention. However, developmental studies have identified multiple ...
Cognitive Function in Post-Menopausal Women with Breast Cancer Treated with Aromatase Inhibitors.
(2014)
Introduction: Cognitive function changes reported as distressing by women diagnosed with breast cancer have been of interest to clinicians and researchers. The majority of post-menopausal women diagnosed with early stage ...
The Road to Identifying Disease Causing Genes: Association Tests, Genotype Imputations, and Sampling Strategies for Sequencing Studies.
(2013)
Technological advances now allow investigators to use sequencing data to identify genetic risk variants for complex diseases. However, it is still expensive to sequence a large sample of individuals. While genotype imputation ...
Characterizing Molecular Modifiers of Pathogenesis in Spinobulbar Muscular Atrophy.
(2015)
Spinobulbar muscular atrophy (SBMA), or Kennedy’s disease, is an inherited neuromuscular disorder caused by a polyglutamine (polyQ) tract expansion in the androgen receptor (AR). This mutation initiates misfolding and ...
Interactions between Hebbian and Homeostatic Synaptic Plasticity in Hippocampal Circuits.
(2014)
Hebbian forms of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), are thought to underlie learning and memory, but these processes may have a destabilizing effect on neural activity. ...
Synthesis and Biochemical Evaluation of Multifunctional Acetylcholinesterase Inhibitor Hybrids for Treatment of Alzheimer's Disease.
(2014)
Alzheimer’s disease (AD) places a significant and dramatically increasing burden on society. While pathological hallmarks of this neurodegenerative disorder are known, the exact cause remains unclear. Acetylcholinesterase ...
Autophagy and Cell Autonomous Neurodegeneration in Niemann-Pick type C Disease.
(2013)
Niemann-Pick type C disease (NPC) is an autosomal recessive lysosomal storage disorder characterized by liver dysfunction and neurodegeneration causing diverse neurologic symptoms such as ataxia, cognitive decline, and ...
Molecular Basis of Inhibitory Modulation of P2X2 Receptors by Zinc and Copper.
(2012)
P2X receptors are ion channels gated by ATP and modulated by the trace metals zinc and copper. Rat P2X2 (rP2X2) receptors show potentiation in the presence of a submaximal concentration of ATP but are inhibited by zinc at ...