Now showing items 371-380 of 409
Continuity and Change in Theory-of-Mind Development: A Neuroscientific Approach.
(2013)
This dissertation seeks a more comprehensive picture of the process of theory-of-mind development (an understanding that action is guided by internal mental states such as beliefs, desires, and intentions) by examining ...
A Role for diaphanous homolog 3 in the Mammalian Auditory System.
(2012)
Inherited deafness is a highly heterogeneous disorder that may be the result of mutations in any one of more than 100 genes. Although the chromosomal locations of these genes have been mapped, the specific gene identities ...
Novel Mechanisms that Antagonize Hedgehog Signaling at the Cell Surface During Vertebrate Embryogenesis
(2017)
Hedgehog (HH) signaling is a conserved mode of cell-cell communication that is indispensible for embryogenesis. HH proteins are secreted ligands that travel over long distances within a developing tissue to induce distinct ...
Cognitive Function, Self-care, and Glycemic Control in Rural Adults with Type 2 Diabetes
(2017)
Cognitive Function, Self-Care, and Glycemic Control in Rural Adults with Type 2 Diabetes
Abstract
The prevalence of type 2 diabetes mellitus (DM) has increased dramatically over the past two decades, particularly among ...
Glucocorticoid regulation of the astrocyte transcriptome in vitro and in vivo.
(2013)
The broad goal of this thesis has been to gain understanding about the influence of cell type on transcriptional regulation in the brain by characterizing glucocorticoid-mediated regulation in astrocytes. Glucocorticoids ...
The Motor Thalamus: An Invigorating Hub of Neural Activity
(2019)
The motor thalamus (Mthal) is poised between subcortical and cortical motor structures and is, in the simplest terms, understood as a “relay” for neural activity. However, it is increasingly appreciated that Mthal plays a ...
Age-Related Neural Dedifferentiation in the Sensorimotor System and its Behavioral Consequences
(2019)
Tens of millions of people experience age-related declines in sensorimotor functioning, but the neurobiological mechanisms underlying this decline are not well understood. Previous studies have linked age-related behavioral ...
Autophagy and Cell-Autonomy in Mouse Models of PI(3,5)P2 Deficiency
(2013)
FIG4 is the 5-phosphatase required for synthesis and turnover of the membrane signaling lipid PI(3,5)P2 (phosphatidylinositol-(3,5)-bisphosphate). Mutation of Fig4 causes neurodegeneration in mice and the neuropathy ...
Effects of Sex and Prenatal Stress on Vulnerability to Drugs.
(2012)
The importance of neurodevelopmental events in utero is well established. When these processes are disrupted, the consequences are severe and long-lasting. Such is the case when prenatal growth overlaps with maternal ...
Mass Spectrometry Based Techniques for In Vivo Neurochemical Monitoring.
(2012)
Neurotransmitter concentration in vivo reflects various behavioral and pharmacological events. Therefore, the measurement of neurochemical dynamics in live behaving animals’ brain is of crucial importance for the fundamental ...