Now showing items 381-390 of 409
Molecular Mechanisms Orchestrating the Dynamics of Secretory Vesicle Pools.
(2015)
The secretion of chemical messengers via Ca2+-dependent exocytosis of vesicles is fundamental to a wide-range of physiological events. Rab GTPases and SNARE proteins govern the temporal and spatial precision of transmitter ...
SOX10-Regulated Promoter Use Defines Isoform-Specific Gene Expression in Schwann Cells
(2019)
To support the development of diverse cell types, multicellular organisms have adopted mechanisms to tailor gene expression profiles to specific spatial and temporal contexts. These mechanisms—including alternative promoter ...
Transmission of Temporal Information Through the Auditory Pathway Measured with Cochlear-Implant Stimulation.
(2013)
Cochlear implants provide the sensation of hearing to deaf individuals through electric stimulation of the auditory nerve. Environmental sounds are band-pass filtered, and the envelope of each frequency band is used to ...
Neurochemical Biomarkers to Assess Mercury's Health Impacts in Birds.
(2012)
Mercury (Hg) is a neurotoxicant that can be associated with changes in neurochemical receptors and enzymes. The hypothesis tested here is that Hg induces changes in neurochemical biomarkers involved in glutamate and ...
The Neurosteroids Allopregnanolone and DHEA Modulate Neurocircuits implicated in Emotion Regulation and Posttraumatic Stress Disorder.
(2013)
The neurosteroids dehydroepiandrosterone (DHEA) and allopregnanolone are integral components of the stress response and exert positive modulatory effects on emotion in human and animal studies. Though these antidepressant ...
Dopamine Contributions to Motivational Vigor and Reinforcement Driven Learning.
(2016)
Brain mechanisms for reinforcement learning and adaptive decision-making are widely accepted to critically involve the basal ganglia (BG) and the neurotransmitter dopamine (DA). DA is a key modulator of synaptic plasticity ...
The Role of Corticotropin-Releasing Hormone-Binding Protein in Binge Drinking and Alcohol Dependence
(2017)
Alcoholism is a chronic and progressive disorder characterized by periods of excessive drinking, withdrawal and abstinence, and eventual relapse. Both genetic and environmental factors contribute to the development of ...
Neurotrophic Factor Signaling Mechanisms Underlying the Development of Peripheral Neural Circuits
(2018)
The first discovery of a growth-regulating signaling molecule was more than 65 years ago, when the work of Rita Levi-Montalcini, Viktor Hamburger, and Stanley Cohen led to the identification and purification of nerve growth ...
Sexual Deprivation, Emotion, and Longevity: Neuropeptidergic Regulation of Aging in Drosophila
(2018)
While researchers often focus on the brain as a victim of aging via neurodegenerative diseases, recent work has demonstrated that the aging process is regulated by neural mechanisms. Thus, we asked which mechanisms and ...
The Effects of REM Sleep Deprivation on Spatial and Reversal Learning.
(2010)
Typically, when REM sleep restriction is applied during learning (concurrent learning) performance is impaired. It is unclear how REM sleep restriction can alter other forms of spatial learning (e.g. reversal learning). ...