Now showing items 391-400 of 409
Who moved my protein? Mechanisms of Epileptogenesis due to Mutations of Voltage-Gated Sodium Channel SCN1B.
(2010)
Voltage-gated sodium channels (VGSCs) play a role in the generation of action potentials in excitable cells, including neurons. VGSCs contain one pore-forming α subunit, one non-covalently linked (β1 or β3) and one covalently ...
Photoperiodic Properties of Circadian Rhythm in Rat.
(2011)
Animals have intrinsic circadian periods of around 24 hours. In order to synchronize to the 24-hour day, circadian rhythms entrain to photic time cues and establish a consistent daily rhythm. The maintenance of a stable ...
Task-Dependence of Spatial Sensitivity in Areas A1, DZ and PAF of Cat Auditory Cortex.
(2010)
Auditory cortex is essential for normal sound localization behavior. Reversible inactivation of primary auditory area (A1), dorsal zone (DZ) or posterior auditory field (PAF) in cats produces varying types and degrees of ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
The Speed of Intravenous Cocaine Delivery Alters its Effect on the Brain and Drug-Taking Behavior: Implications for Addiction Liability.
(2010)
Cocaine addiction in humans is a severe health and social problem. Therefore, understanding how casual use transforms into addiction is critical. One of the many factors that can facilitate addiction is how rapidly drugs ...
Exploration and Exploitation of Action Selection in the Motor Cortex and Basal Ganglia.
(2010)
The basal ganglia (BG) have been proposed as a possible neural substrate for action selection in the vertebrate brain. In this thesis, I have focused on determining the role of BG circuits in selection of well-trained ...
Interplay Between Default-Mode and Task-Positive Networks: Functional Characterization of the Brain's Large-Scale Neural Systems.
(2010)
Recent work has demonstrated that the human brain is functionally organized into distinct large-scale networks, with particular attention focused on the default-mode network (DMN) and the anti-correlated “task-positive” ...
Coordination of Eye and Head Movements in Cavia Porcellus.
(2011)
The present work provides novel insights into the coordination of vestibular reflexes in the head-unrestrained guinea pig. Eye and head movements were recorded during passive whole body rotations and active head movements. ...
Corticostriatal Plasticity, Learning and Choice.
(2011)
The striatum, the entry point for a wide range of information into the basal ganglia, is perhaps the most critical information processing region in this brain system. In addition to playing a role in the facilitation and ...
Role of CHD7 in Neural Development and Maintenance.
(2011)
Normal tissue development and maintenance require precise timing and correct localization of gene expression. Several lines of evidence indicate that the chromodomain (CHD) family of proteins are critical regulators of ...