Now showing items 401-409 of 409
Hypocretin-1 and GABA in the Pontine Reticular Formation Interact to Promote Wakefulness.
(2010)
Hypocretin-1 and hypocretin-2 are wake-promoting neuropeptides that are exclusively synthesized in the lateral hypothalamus. Hypocretin deficiency underlies the sleep disorder narcolepsy, which is characterized by excessive ...
circadian and Homeostatic Components of Sleep across Sex and Development in the Diurnal Rodent, Octodon degus.
(2011)
This dissertation examined the impact of sex and development on sleep in the diurnal rodent, Octodon degus. All experiments utilized electrophysiological measures to quantify sleep patterns, brain temperature and locomotor ...
Bi-directional Interactions between Cognition and Circadian Rhythms.
(2011)
Circadian rhythms are ubiquitous and dynamic, allowing organisms to adapt and anticipate key environmental cues under a variety of conditions. Circadian systems are also complex regulatory mechanisms, involving the ...
From Gene to Brain and Behavior: Dopaminergic Effects on Motor Sequence Learning in Parkinson's Disease.
(2011)
Parkinson’s disease (PD) is a neurodegenerative disorder affecting the dopamine neurotransmitter system which is crucial for motor control and cognitive function. Dopaminergic medications alleviate Parkisonian motor symptoms ...
Memory, Interference and Depression.
(2010)
This dissertation explores the role of interference in short-term memory and how interference in memory may influence depression. The first chapter tackles whether forgetting in the short-term is due to decay with the ...
Fast Capillary Electrophoresis for the Study of Dopamine in the Central Nervous System.
(2011)
The study of neurochemical events in the central nervous system (CNS) with temporal resolution ranging from seconds to minutes facilitates the evaluation of intercellular communication on times scales that are relevant to ...
Key Mechanisms Regulating Synaptic and Cell Wide Forms of Homeostatic Plasticity.
(2011)
Sustained alterations in neuron activity elicit compensatory changes in synaptic function, a form of adaptation known as homeostatic plasticity. Homeostatic forms of plasticity are thought to maintain neural circuit ...
The Impact of Serotonin Transporter Gene Variation on Neural and Behavioral Correlates of Goal-Directed Cognition
(2011)
In order to enable goal-directed behavior in a dynamically changing environment, the human brain must meet two competing requirements: (1) the goal representations must be stably and robustly maintained in the face of ...
Pubertal hormones alter circadian timekeeping: Evidence from two rodent models, Rattus norvegicus and Octodon degus.
(2010)
There is overwhelming evidence that the circadian timekeeping system is sensitive to gonadal hormones during perinatal development and adulthood. However, there is a noticeable lack of research in animal models focusing ...