Now showing items 141-147 of 147
How Sweet It Is: The Role of Taste Perception in Diet-Induced Obesity
(2020)
Our ability to taste sugar evolved to tell us that certain foods are good to eat because they provide us with energy. However, in the modern food environment of ubiquitous “added sugars”, this good taste can be hijacked ...
Symmetric Neural Progenitor Divisions Require Chromatin-Mediated Homology-Directed DNA Repair
(2021)
The cerebral cortex is generated by a highly coordinated series of cellular proliferations, beginning with symmetric neural progenitor cell (NPC) divisions to expand the pool of progenitors, and subsequent asymmetric NPC ...
Autophagy and Cell-Autonomy in Mouse Models of PI(3,5)P2 Deficiency
(2013)
FIG4 is the 5-phosphatase required for synthesis and turnover of the membrane signaling lipid PI(3,5)P2 (phosphatidylinositol-(3,5)-bisphosphate). Mutation of Fig4 causes neurodegeneration in mice and the neuropathy ...
SOX10-Regulated Promoter Use Defines Isoform-Specific Gene Expression in Schwann Cells
(2019)
To support the development of diverse cell types, multicellular organisms have adopted mechanisms to tailor gene expression profiles to specific spatial and temporal contexts. These mechanisms—including alternative promoter ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Role of CHD7 in Neural Development and Maintenance.
(2011)
Normal tissue development and maintenance require precise timing and correct localization of gene expression. Several lines of evidence indicate that the chromodomain (CHD) family of proteins are critical regulators of ...
Mimicking partial to total placental insufficiency in a rabbit model of cerebral palsy
(Springer International PublishingWiley Periodicals, Inc., 2022-12)
All placental abruptions begin as partial abruptions, which sometimes manifest as fetal bradycardia. The progression from partial to total abruption was mimicked by a new rabbit model of placental insufficiency, and we ...