Now showing items 21-30 of 147
Early NFΚB activation is inhibited during focal cerebral ischemia in interleukin-1Β-converting enzyme deficient mice
(Wiley Subscription Services, Inc., A Wiley Company, 2003-09-01)
Our previous study demonstrated that the inhibition of interleukin-1Β (IL-1Β) reduces ischemic brain injury; however, the molecular mechanism of the action of IL-1 in cerebral ischemia is unclear. We are investigating ...
Acetylcholine-evoked calcium increases in Deiters' cells of the guinea pig cochlea suggest Α9-like receptors
(John Wiley & Sons, Inc., 2001-02-01)
The medial efferent system innervates outer hair cells in the organ of Corti. Neurotransmission at this synapse is mediated by acetylcholine (ACh) acting on nicotinic ACh receptors containing the Α9 subunit. In addition ...
Proportional myoelectric control of a virtual object to investigate human efferent control
(Springer-Verlag, 2004-12)
We used proportional myoelectric control of a one-dimensional virtual object to investigate differences in efferent control between the proximal and distal muscles of the upper limbs. Eleven subjects placed one of their ...
Overview of Gene Targeting by Homologous Recombination
(Wiley Periodicals, Inc., 2002-10)
Overview of Gene Targeting by Homologous Recombination (Richard Mortensen, University of Michigan Medical School, Ann Arbor, Michigan).This overview describes the basic methodology and applications of homologous recombination. ...
Tracking Quantum Dot–Tagged Calcium Channels at Vertebrate Photoreceptor Synapses: Retinal Slices and Dissociated Cells
(Wiley Periodicals, Inc., 2013-01)
At synapses in the central nervous system, precisely localized assemblies of presynaptic proteins, neurotransmitter‐filled vesicles, and postsynaptic receptors are required to communicate messages between neurons. Our ...
Analyzing Binding Data
(Academic PressWiley Periodicals, Inc., 2010-07)
Measuring the rate and extent of radioligand binding provides information on the number of binding sites, and their affinity and accessibility of these binding sites for various drugs. This unit explains how to design and ...
Hippocampal involvement in contextual modulation of fear extinction
(Wiley Subscription Services, Inc., A Wiley Company, 2007-09)
Extinction of fear conditioning in animals is an excellent model for the study of fear inhibition in humans. Substantial evidence has shown that extinction is a new learning process that is highly context-dependent. Several ...
Remodeling of cholinergic input to the hippocampus after noise exposure and tinnitus induction in Guinea pigs
(John Wiley & Sons, Inc., 2019-08)
Here, we investigate remodeling of hippocampal cholinergic inputs after noise exposure and determine the relevance of these changes to tinnitus. To assess the effects of noise exposure on the hippocampus, guinea pigs were ...
Overview of Gene Targeting by Homologous Recombination
(Wiley Periodicals, Inc., 2007-07)
The analysis of mutant organisms and cell lines is important in determining the function of specific proteins. Recent technological advances in gene targeting by homologous recombination in mammalian systems enable the ...
Methanol exposure interferes with morphological cell movements in the Drosophila embryo and causes increased apoptosis in the CNS
(Wiley Subscription Services, Inc., A Wiley Company, 2004-09-05)
Despite the significant contributions of tissue culture and bacterial models to toxicology, whole animal models for developmental neurotoxins are limited in availability and ease of experimentation. Because Drosophila ...