Now showing items 61-70 of 147
Do cortical plasticity mechanisms differ between males and females?
(Wiley Periodicals, Inc., 2017-01-02)
Assessment of muscarinic receptor concentrations in aging and Alzheimer disease with [ 11 C]NMPB and PET
(John Wiley & Sons, Inc., 2001-03-15)
Cerebral cholinergic deficits have been described in Alzheimer disease (AD) and as a result of normal aging. At the present time, there are very limited options for the quantification of cholinergic receptors with in vivo ...
Calcineurin activation contributes to noise-induced hearing loss
(Wiley Subscription Services, Inc., A Wiley Company, 2004-11-01)
Acoustic overstimulation increases Ca 2+ concentration in auditory hair cells. Because calcineurin is known to activate cell death pathways and is controlled by Ca 2+ and calmodulin, this study assessed the role of ...
William Hogarth, Unwitting Neurochemist?
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2000-10)
William Hogarth's famous etching Gin Lane is often used to illustrate the debilitating results of alcohol addiction. Less well known is the companion etching Beer Street in which death, murder and squalor are replaced by ...
Repeated apomorphine administration alters dopamine D1 and D2 receptor densities in pigeon basal telencephalon
(Springer-Verlag, 2005-01)
When pigeons are repeatedly administered a dose of apomorphine they show an increasing behavioral response, much as rodents do. In birds this expresses itself in an augmented pecking response. This sensitization is assumed ...
Expression of excitatory amino acid transporter interacting protein transcripts in the thalamus in schizophrenia
(Wiley Subscription Services, Inc., A Wiley Company, 2006-06-01)
The excitatory amino acid transporters (EAATs) are a family of plasma membrane proteins that maintain synaptic glutamate concentration by removing glutamate from the synaptic cleft. EAATs are expressed by glia (EAAT1 and ...
Ionotropic glutamate receptor modulation preferentially affects NMDA receptor expression in rat hippocampus
(John Wiley & Sons, Inc., 2000-12-01)
Electrophysiological data suggest that alterations in the function of one glutamate receptor subtype may affect the function of other subtypes. Further, previous studies have demonstrated that NMDA receptor antagonists ...
Production of a Heterozygous Mutant Cell Line by Homologous Recombination (Single Knockout)
(IRL PressWiley Periodicals, Inc., 2002-10)
Gene targeting by homologous recombination allows the introduction of specific mutations into any cloned gene. This unit provides a protocol in which the gene of interest is inactivated by interrupting its coding sequence ...
Prolonged seizures recruit caudal subventricular zone glial progenitors into the injured hippocampus
(Wiley Subscription Services, Inc., A Wiley Company, 2006)
Neurogenesis persists in the adult rat rostral forebrain subventricular zone (SVZ) and is stimulated by status epilepticus (SE). More caudal SVZ (cSVZ) neural progenitors migrate to the hippocampus after ischemic injury ...
Input source and strength influences overall firing phase of model hippocampal CA1 pyramidal cells during theta: Relevance to REM sleep reactivation and memory consolidation
(Wiley Subscription Services, Inc., A Wiley Company, 2006-02)
In simulation studies using a realistic model CA1 pyramidal cell, we accounted for the shift in mean firing phase from theta cycle peaks to theta cycle troughs during rapid-eye movement (REM) sleep reactivation of hippocampal ...