Now showing items 71-80 of 148
Effects of 6-cyano-7-nitroquinoxaline-2,3-dione on nicotinic receptor subunit transcript expression in the rat brain
(Wiley Subscription Services, Inc., A Wiley Company, 2004-04)
The nicotinic cholinergic system exerts potent modulatory effects on glutamatergic neurotransmission, an effect mediated in part by increased glutamate release following activation of presynaptic nicotinic cholinergic ...
Differential propagation of ripples along the proximodistal and septotemporal axes of dorsal CA1 of rats
(John Wiley & Sons, Inc., 2020-09)
The functional connectivity of the hippocampus with its primary cortical input, the entorhinal cortex, is organized topographically. In area CA1 of the hippocampus, this leads to different functional gradients along the ...
A mouse embryonic stem cell model of Schwann cell differentiation for studies of the role of neurofibromatosis type 1 in Schwann cell development and tumor formation
(Wiley Subscription Services, Inc., A Wiley Company, 2007-08-15)
The neurofibromatosis Type 1 (NF1) gene functions as a tumor suppressor gene. One known function of neurofibromin, the NF1 protein product, is to accelerate the slow intrinsic GTPase activity of Ras to increase the production ...
Hypoxia modulates cholinergic but not opioid activation of G proteins in rat hippocampus
(Wiley Subscription Services, Inc., A Wiley Company, 2007-10)
Intermittent hypoxia, such as that associated with obstructive sleep apnea, can cause neuronal death and neurobehavioral dysfunction. The cellular and molecular mechanisms through which hypoxia alter hippocampal function ...
Spatial representation of corticofugal input in the inferior colliculus: a multicontact silicon probe approach
(Springer-Verlag, 2003-12)
The inferior colliculus (IC) is a well-established target of descending projections from the auditory cortex (AC). However, our understanding of these pathways has been limited by an incomplete picture of their functional ...
Effects of contralateral sound stimulation on unit activity of ventral cochlear nucleus neurons
(Springer-Verlag, 2003-12)
The cochlear nucleus (CN) commissural connection represents the first opportunity for convergence of binaural information in the auditory brainstem. All major neuron types in the ventral CN (VCN) are innervated by a diverse ...
Nicotine effects on regional cerebral blood flow in awake, resting tobacco smokers
(John Wiley & Sons, Inc., 2000-12-01)
The hypothesis for this research was that regional cerebral blood flow (rCBF) would increase following nasal nicotine administration to overnight abstinent tobacco smokers in relationship to the known brain distribution ...
( R )- N -[ 11 C]methyl-3-pyrrolidyl benzilate, a high-affinity reversible radioligand for PET studies of the muscarinic acetylcholine receptor
(Wiley Subscription Services, Inc., A Wiley Company, 2002-07)
We recently reported the synthesis and binding affinity of ligands for the muscarinic acetylcholine receptor (mAChR) based on both the pyrrolidyl and piperidyl benzilate scaffold. One of these, ( R )-3-pyrrolidyl benzilate, ...
Rapid and differential losses of in vivo dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) radioligand binding in MPTP-treated mice
(John Wiley & Sons, Inc., 2000-03-15)
The dose- and time-dependent changes of in vivo radioligand binding to the neuronal membrane dopamine transporter (DAT) and vesicular monoamine transporter type 2 (VMAT2) were examined in mouse brain after MPTP ...
Super-stereotypy II: Enhancement of a complex movement sequence by intraventricular dopamine D1 agonists
(John Wiley & Sons, Inc., 2000-09-01)
This study compared the effect of intraventricular administration of dopamine D1 or D2 agonists or of ACTH on the sequential stereotypy of a serial pattern of grooming movements (“syntactic chain”). In a previous study, ...