Now showing items 71-80 of 103
Pharmacological profile of a potent, efficacious fentanyl derivative in rhesus monkeys
(Springer-Verlag, 1992-11)
The recent synthesis of fentanyl derivatives, some of which appear to have novel profiles of pharmacological effects, has provided compelling evidence that μ opioid efficacy might be altered systematically by modifications ...
Characterization of pro-opiomelanocortin processing in heterologous neuronal cells that express PC2 mRNA
(Elsevier, 1993-05)
We have investigated processing of monkey pro-opiomelanocortin (POMC) following transfection into heterologous neuronal Neuro 2A (N2A) cells. In several separately transfected stable cell lines (termed N2A/POMC2-like; N = ...
Wortmannin Blocks Goldfish Retinal Phosphatidylinositol 3-Kinase and Neurite Outgrowth
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1997-04)
The goldfish retina has been used extensively for the study of nerve regeneration. A role for phosphatidylinositol 3-kinase (PI3K) in neurite outgrowth from goldfish retinal explants has been examined by means of wortmannin ...
Controlled dosing of nicotine via an I ntranasal N icotine A erosol D elivery D evice (INADD)
(Springer-Verlag, 1992-09)
The present report describes an I ntranasal N icotine A erosol D elivery D evice (INADD) employing an artist's airbrush as aerosolizer and precise, electromechanical control of spray duration. It was designed for the ...
Reinforcing and discriminative stimulus effects of the neuroactive steroids pregnanolone and Co 8-7071 in rhesus monkeys
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-07)
Rationale and Objectives : The present study was designed to assess possible abuse-related effects of the endogenous neuroactive steroid pregnanolone (3α-hydroxy-5β-pregnan-20-one) and the orally bioavailable, water-soluble ...
Cloning and characterization of a pharmacologically distinct A1 adenosine receptor from guinea pig brain
(Elsevier, 1994-10)
Three full-length cDNA clones encoding the guinea pig A1 adenosine receptor have been isolated by polymerase chain reaction (PCR) and low-stringency hybridization screening of a guinea pig brain cDNA library. These three ...
Systemic effects of E-2078, a stabilized dynorphin A(1–8) analog, in rhesus monkeys
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-04)
Rationale : E-2078 ([ N -methyl-Tyr 1 , N -methyl-Arg 7 , d -Leu 8 ] dynorphin A(1–8) ethylamide) is a dynorphin A(1–8) analog with a reduced tendency to be biotransformed, when compared to the unmodified opioid peptide. ...
Characterization of [beta]-endorphin-related peptides in the caudal medulla oblongata and hypothalamus of the prenatal, postnatal and adult rat
(Elsevier, 1991-09-19)
A comparison was made of [beta]-endorphin (B-END) concentrations versus post-translation products during the perinatal period in the hypothalamus and the caudal medulla oblongata. The concentration of B-END-like immunoreactivity ...
Coupling an [alpha]2-Adrenergic receptor peptide to G-protein: A new photolabeling agent
(Elsevier, 1994)
A photoreactive derivative of a tetradecapeptide G-protein activator (peptide Q) derived from the [alpha]2-adrenergic receptor was designed and used to label purified G-protein (Go/Gi). N-bromoacetyl-N'-(3-diazopyruvoyl) ...
The Role of the Hippocampal Mineralocorticoid and Glucocorticoid Receptors in the Hypothalamo-Pituitary-Adrenal Axis of the Aged Fisher Rat
(Elsevier, 1994-10)
The aging process has been frequently associated with hippocampal neuredegeneration, loss of corticosteroid receptors, and, at the same time, dysfunction of the hypothalamo-pituitary-adrenal (HPA) axis. We were interested ...