Now showing items 21-30 of 259
Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats
(Springer-Verlag, 2005-11)
Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression ...
Effects of neuropeptide Y, insulin, 2-deoxyglucose, and food deprivation on food-motivated behavior
(Springer-Verlag, 1995-08)
The current study demonstrates the ability of neuropeptide Y (NPY) to increase break points under a progressive ratio 1 (PR1) reinforcement schedule. An initial response resulted in delivery of a food reinforcer (45 mg ...
Levels and distribution of central nervous system amines in normal and morphine-dependent monkeys
(Elsevier, 1972-03)
The distribution of norepinephrine, dopamine and 5-hydroxytryptamine in various areas of the CNS of the normal monkey has been presented.The central levels and distribution of norepinephrine, dopamine and 5-hydroxytryptamine ...
Glucocorticoid-reinforced responding in the rhesus monkey
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-11)
Rationale: Glucocorticoids have been reported to have rewarding effects in rats and may lead to drug-seeking behavior in humans under some circumstances. Objectives: The present study investigated whether glucocorticoids ...
Electroencephalographic assessment of the role of [delta] receptors in opioid peptide - induced seizures
(Elsevier, 1984-12)
DPDPE ([D-Pen2, D-Pen5]-Enkephalin) and DPLPE ([D-Pen2, L-Pen5]-Enkephalin) are conformationally-constrained cyclic analogs of enkephalin with high selectivity for [delta] opioid receptors. Intracerebroventricular (i.c.v.) ...
Strategies for studying opioid peptide regulation at the gene, message and protein levels
(Elsevier, 1984)
Three opioid peptide precursors have been isolated and characterized in endocrine and nervous tissue: pro-opiomelanocortin, pro-enkephalin, and pro-dynorphin. Since each of those opioid peptide systems have been extensively ...
Naloxone enhancement of DMT and LSD-25 induced suppression of food-rewarded bar pressing behavior in the rat
(Springer-Verlag, 1979-01)
The narcotic antagonist naloxone was tested to determine its possible interaction with N,N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) in adult male Holtzman rats trained to press a bar on a fixed-ratio ...
Contribution of social factors to opiate-induced activation in the mouse
(Elsevier, 1981-04)
Adult male Swiss-Webster mice of varying group size (single, or in groups of 2, 3, or 4) were injected with vehicle, or 25 or 50 mg/kg of morphine sulfate. In comparison with vehicle, morphine-injected mice showed heightened ...
Discriminative stimulus effects of pentobarbital in rhesus monkeys: Tests of stimulus generalization and duration of action
(Springer-Verlag, 1982-02)
Rhesus monkeys were trained to emit 20 or 30 consecutive responses on one lever following an IM injection of pentobarbital (10 or 18 mg/kg) and the same number of consecutive responses on another lever following an injection ...
GABA involvement in memory consolidation: Evidence from posttrial amino-oxyacetic acid
(Springer-Verlag, 1978-01)
In order to assess the possible effects of central GABA activation on the consolidation of shock avoidance, the GABA-T inhibitor amino-oxyacetic acid (AOAA) was administered posttrial to adult male rats. Learning was ...