Now showing items 111-120 of 209
Cholinergic agonist-antagonist interactions on neocortical and limbic EEG activation
(Elsevier, 1967-09)
The effects of various cholinergic agonists and antagonists and their interactions were determined on the awake-sleep cycle of cats with chronic indwelling brain electrodes. The effects were measured by the use of the EEG ...
Central muscle relaxant effects of diazepam
(Elsevier, 1970-09)
Motor depressant effects of diazepam were studied in the intact, decerebrate and high spinal cat. Diazepam (0[middle dot]125-16 mg/kg i.v.) produced a depression of both the patellar and linguomandibular reflexes in the ...
Cholinergic properties of desipramine and amoxapine: Assessment using a thermoregulation paradigm
(Elsevier, 1987)
1. 1. The withdrawal of tricyclic antidepressants (TCAs) produces symptoms suggesting cholinergic rebound.2. 2. Amitriptyline (AMI), the most potent antimuscarinic agent among this class of drugs, produces supersensitivity ...
Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice
(Springer-Verlag, 2004-05)
No selective antagonists for the effects of MDMA have yet been identified. The structurally-similar, naturally-occurring plant alkaloid nantenine (9,10-methylenedioxy-1,2 dimethoxyaporphine) may represent such a compound.
Distribution of D2 dopamine receptor mRNA in the primate brain
(Elsevier, 1991)
1. The distribution of the messenger RNA (mRNA) encoding the D2dopamine receptor has been mapped in the monkey brain by hybridization.2. Using [35s]-labelled riboprobes corresponding to the region of the D2 dopamine ...
Similarity of the discriminative stimulus effects of ketamine, cyclazocine, and dextrorphan in the pigeon
(Springer-Verlag, 1981-05)
Separate groups of pigeons were trained to discriminate the IM injection of ketamine, cyclazocine, or dextrorphan from saline. Each of the training drugs and phencyclidine produced dose-related, drug-appropriate responding ...
Comparison of acute and chronic lithium treatment on 3 H-norepinephrine uptake by rat brain slices
(Springer-Verlag, 1980-01)
The effects of lithium chloride, given IP in high (2.5–15 mEq/kg) and low (1.25 mEq/kg) doses twice daily, upon 3 H-norepinephrine uptake and retention were examined with slices from four regions of the rat brain, namely ...
Effects of chlorpromazine on some motor reflexes,
(Elsevier, 1963-08)
The effects of chlorpromazine (CPZ) on the patellar reflex and segmentally evoked spinal cord potentials were determined in various cat preparations. CPZ in doses of 1-8 mg/kg given intravenously (as an accumulative dose) ...
The effects of antidepressants on the retention and metabolism of [3H]-norepinephrine in rat brain slices
(Elsevier, 1981-04)
Tricylic antidepressants acutely decrease the neuronal retention of [3H]-norepinehrine ([3H]-NE) by blocking neuronal membrane uptake and/or vesicular uptake and binding. To distinguish between effects upon the plasma ...
Interaction of synthetic opioid metenkephalin peptide analogs, lilly 127623 and FK 33-824 with indole hallucinogens: Antagonism of N,N-dimethyltryptamine- and LSD-induced disruption of food-rewarded bar pressing behavior in the rat
(Springer-Verlag, 1983-07)
The selected opioid metenkephalin synthetic peptide analogs Lilly (LY) 127623 and FK 33-824 were tested for behavioral dose effects and potential interaction with N,N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 ...