Now showing items 151-160 of 209
Pharmacological patterns in subcortical reinforcement behavior
(Elsevier, 1963-12)
By means of intercurrent hypothalamic positive reinforcement and tegmental negative reinforcement tests, drug actions on two different brain-stimulated behaviors were assessed simultaneously. Chlorpromazine at 2 mg/kg was ...
Effects of anxiety-relieving drugs on unit discharges in hippocampus, reticular midbrain, and pre-optic area in the freely moving rat
(Elsevier, 1969-03)
The effects on unit discharges of various doses of the compounds chlordiazepoxide, meprobamate, sodium pentobarbital, and diazepam were studied in the unanesthetized, unrestrained rat. Recordings of action potentials were ...
Opioid but not nonopioid stress-induced analgesia is enhanced following prenatal exposure to ethanol
(Springer-Verlag, 1985-01)
Two neurochemically distinct forms of stress-induced analgesia were examined in adult rats following prenatal ethanol exposure. Rats were exposed to ethanol during the last 2 weeks of gestation through a liquid diet presented ...
Clocinnamox antagonism of opioid suppression of schedule-controlled responding in rhesus monkeys
(Springer-Verlag, 1996-02)
The antagonist effects of clocinnamox were evaluated against opioid agonists, acting at μ, κ and ∂-receptors, in rhesus monkeys ( n =3–4) responding under a fixed-ratio 30 (FR 30) schedule for food delivery. Clocinnamox ...
Clocinnamox inhibits the intravenous self-administration of opioid agonists in rhesus monkeys: comparison with effects on opioid agonist-mediated antinociception
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1997-02)
The effects of CCAM, an insurmountable mu opioid receptor antagonist, were studied on the intravenous self-administration and thermoantinociception of alfentanil and nalbuphine, high- and low-efficacy opioid agonists, ...
Desipramine attenuates working memory impairments induced by partial loss of catecholamines in the rat medial prefrontal cortex
(Springer-Verlag, 2006-01)
The density of tyrosine hydroxylase-immunoreactive (TH-IR) axons in the prefrontal cortex of schizophrenic subjects may be reduced by as much as 50% in the deep cortical layers (Am J Psychiatry 156:1580–1589, 1999). ...
Acute effects of high-dose thyrotropin releasing hormone infusions in Alzheimer's disease
(Springer-Verlag, 1989-07)
Thyrotropin releasing hormone (TRH) was administered intravenously to ten patients with Alzheimer's Disease (AD) in a high-dose paradigm, thought to maximize central nervous system effects and potentially produce facilitation ...
TRH attenuates scopolamine-induced memory impairment in humans
(Springer-Verlag, 1990-03)
The brain tripeptide thyrotropin-releasing hormone (TRH) has been demonstrated to facilitate cholinergic neurotransmission. To test its interaction with the cholinergic system in humans, high-dose TRH (0.5 mg/kg) or placebo ...
Comparison of naltrexone and quaternary naltrexone after systemic and intracerebroventricular administration in pigeons
(Elsevier, 1987-06)
The behavioral effects of naltrexone and quaternary naltrexone were evaluated in two groups of pigeons. One group responded under a fixed-ratio schedule of food reinforcement and was trained to discriminate between 3.2 ...
Pharmacological profile of a potent, efficacious fentanyl derivative in rhesus monkeys
(Springer-Verlag, 1992-11)
The recent synthesis of fentanyl derivatives, some of which appear to have novel profiles of pharmacological effects, has provided compelling evidence that μ opioid efficacy might be altered systematically by modifications ...