Now showing items 161-170 of 209
Determinants of the behavioral effects of opioids and their antagonists: contributions of the Laboratory of Psychobiology
(Springer-Verlag, 2002-10)
Abstract
Controlled dosing of nicotine via an I ntranasal N icotine A erosol D elivery D evice (INADD)
(Springer-Verlag, 1992-09)
The present report describes an I ntranasal N icotine A erosol D elivery D evice (INADD) employing an artist's airbrush as aerosolizer and precise, electromechanical control of spray duration. It was designed for the ...
Discriminative stimulus effects of N-substituted analogs of phencyclidine in rhesus monkeys
(Elsevier, 1982-12)
In daily sessions of a two-lever, discrete-trial, food-reinforced procedure, rhesus monkeys were trained to discriminate between subcutaneous injections of ketamine (1.0 or 1.8 mg/kg) and control injections. In tests of ...
Reinforcing and discriminative stimulus effects of the neuroactive steroids pregnanolone and Co 8-7071 in rhesus monkeys
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-07)
Rationale and Objectives : The present study was designed to assess possible abuse-related effects of the endogenous neuroactive steroid pregnanolone (3α-hydroxy-5β-pregnan-20-one) and the orally bioavailable, water-soluble ...
Social defeat alters the acquisition of cocaine self-administration in rats: role of individual differences in cocaine-taking behavior
(Springer-Verlag, 2001-12)
Rationale : It is known that social defeat can modulate cocaine self-administration. However, it is unclear whether this psychosocial stressor affects drug-taking behavior to the same extent across all individual animals, ...
Environmental modulation of the response to amphetamine: dissociation between changes in behavior and changes in dopamine and glutamate overflow in the rat striatal complex
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2000-08)
Rationale: We have previously shown that environmental novelty enhances the behavioral activating effects of amphetamine and amphetamine-induced expression of the immediate early gene c- fos in the striatal complex, ...
Systemic effects of E-2078, a stabilized dynorphin A(1–8) analog, in rhesus monkeys
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-04)
Rationale : E-2078 ([ N -methyl-Tyr 1 , N -methyl-Arg 7 , d -Leu 8 ] dynorphin A(1–8) ethylamide) is a dynorphin A(1–8) analog with a reduced tendency to be biotransformed, when compared to the unmodified opioid peptide. ...
Dopaminergic involvement in attention a novel animal model
(Elsevier, 1981)
1. 1. Adult male outbred albino mice were acutely injected with either of two dopamine (DA) agonists; Apomorphine, a receptor agonist, or Amantadine, a DA releasing agent.2. 2. Both drugs produced dose-related alterations ...
A statistical approach for classifying change in cognitive function in individuals following pharmacologic challenge: an example with alprazolam
(Springer-Verlag, 2006-05)
The effects of any drug treatment on cognitive function are typically studied in groups of subjects. Observations made about the behavior of the drug, in the study sample, are then generalized to the population from which ...
Brain acetylcholine in morphine pellet implanted rats given naloxone
(Springer-Verlag, 1975-01)
Adult male rats were implanted with intraventricular (ivt.) brain cannulae for injection of 5 Μg of acetylseco-hemicholinium-3 (acetylseco HC-3) as a means of studying acetylcholine (ACh) utilization during morphine ...