Now showing items 21-30 of 176
Axial level‐specific regulation of neuronal development: Lessons from PITX2
(Wiley Periodicals, Inc., 2015-02)
Delayed neurotrophin treatment following deafness rescues spiral ganglion cells from death and promotes regrowth of auditory nerve peripheral processes: Effects of brain-derived neurotrophic factor and fibroblast growth factor
(Wiley Subscription Services, Inc., A Wiley Company, 2007-07)
The extent to which neurotrophic factors are able to not only rescue the auditory nerve from deafferentation-induced degeneration but also promote process regrowth is of basic and clinical interest, as regrowth may enhance ...
Super-stereotypy I: Enhancement of a complex movement sequence by systemic dopamine D1 agonists
(John Wiley & Sons, Inc., 2000-09-01)
Peripheral administration of D1 dopamine agonists elicits grooming behavior from rodents. The present study examined grooming behavior and the relative probability and stereotypy of a natural sequence of grooming movements ...
Heat shock factor 1-deficient mice exhibit decreased recovery of hearing following noise overstimulation
(Wiley Subscription Services, Inc., A Wiley Company, 2005-08-15)
Heat shock proteins (Hsps) can enhance cell survival in response to stress. Heat shock factor 1 (Hsf1) is the major transcription factor that regulates stress-inducible Hsp expression. We previously demonstrated the ...
Structure specific analysis of the hippocampus in temporal lobe epilepsy
(Wiley Subscription Services, Inc., A Wiley Company, 2009-06)
The hippocampus is a major structure of interest affected by temporal lobe epilepsy (TLE). Region of interest (ROI)-based analysis has traditionally been used to study hippocampal involvement in TLE, although spatial ...
Glycine Protection of PC-12 Cells Against Injury by ATP-Depletion
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2003-06)
A distinctive mechanism of cell injury during ATP depletion involves the loss of cellular glycine. The current study examined whether provision of glycine during ATP depletion can prevent injury in PC-12 cells, a cell line ...
Intratumoral injection of BCNU in ethanol (DTI-015) results in enhanced delivery to tumor – a pharmacokinetic study
(Kluwer Academic Publishers; Springer, 2005-07)
Solvent facilitated perfusion (SFP) has been proposed as a technique to increase the delivery of chemotherapeutic agents to tumors. SFP entails direct injection of the agent into the tumor in a water-miscible organic ...
Early NFΚB activation is inhibited during focal cerebral ischemia in interleukin-1Β-converting enzyme deficient mice
(Wiley Subscription Services, Inc., A Wiley Company, 2003-09-01)
Our previous study demonstrated that the inhibition of interleukin-1Β (IL-1Β) reduces ischemic brain injury; however, the molecular mechanism of the action of IL-1 in cerebral ischemia is unclear. We are investigating ...
Acetylcholine-evoked calcium increases in Deiters' cells of the guinea pig cochlea suggest Α9-like receptors
(John Wiley & Sons, Inc., 2001-02-01)
The medial efferent system innervates outer hair cells in the organ of Corti. Neurotransmission at this synapse is mediated by acetylcholine (ACh) acting on nicotinic ACh receptors containing the Α9 subunit. In addition ...
Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
(Kluwer Academic Publishers; Springer, 2005-06)
Tamoxifen has been a mainstay of adjuvant therapy for breast cancer for many years. We sought to determine if genetic variability in the tamoxifen metabolic pathway influenced overall survival in breast cancer patients ...