Now showing items 191-197 of 197
Incorporating Deep Learning Techniques into Outcome Modeling in Non-Small Cell Lung Cancer Patients after Radiation Therapy
(2020)
Radiation therapy (radiotherapy) together with surgery, chemotherapy, and immunotherapy are common modalities in cancer treatment. In radiotherapy, patients are given high doses of ionizing radiation which is aimed at ...
Targeting the Hsp90 Molecular Chaperone and Resistant Pathways in BRAF-mutant Melanoma
(2020)
Melanoma remains the most aggressive and fatal type of skin cancer. In greater than 50% of cases, patients present with an activating BRAF mutation (BRAF+), leading to upregulated mitogen-activated protein kinase (MAPK) ...
Gut Microbiota Modulate CD8 T Cell Responses to Influence Colitis-Associated Tumorigenesis
(2020)
The gut microbiome plays important physiological roles, including aiding in digestion of non-digestible starches and fibers, production of nutrients, protection against pathogens, as well as inducing mucosal immune system ...
Isolation and Characterization of Circulating Biomarkers to Predict Patient Outcomes in Late-Stage Non-Small Cell Lung Cancer
(2021)
This work hypothesizes that the molecular characterization of extracellular vesicles (EVs) and circulating tumor cells (CTCs), biomarkers found in peripheral blood draws, can be used to monitor, and predict, treatment ...
Incidence and management of pleural effusions in patients with Wilms tumor: A Pediatric Surgical Oncology Research Collaborative study
(John Wiley & Sons, Inc., 2022-11-15)
Wilms tumor (WT) is the most common renal malignancy in children. Children with favorable histology WT achieve survival rates of over 90%. Twelve percent of patients present with metastatic disease, most commonly to the ...
Engineering Multifunctional Nanoparticles: Applied Nanoscale Therapeutics
(2022)
Decades of research towards the development of nanomedicines have, to date, yielded minimal
clinical impact. Focused particularly on the treatment of cancer, the relatively low
number of pursued technologies to reach the ...
Prevention Strategies for Gynecologic Cancers
(2022)
This dissertation focused on prevention strategies for ovarian and cervical cancers. Primary prevention of ovarian cancer was explored in Aim 1 using data from the Ovarian Cancer Association Consortium (OCAC; 7,743 cases; ...