Now showing items 31-40 of 72
Pathophysiology of acute graft-versus-host disease
(John Wiley & Sons, Ltd., 2003-12)
Graft-versus-host disease (GVHD) has been the primary limitation to the wider application of allogeneic bone marrow transplantation (BMT). The pathophysiology of acute GVHD is complex and can be conceptualized to be a ...
Instructions for Authors
(Kluwer Academic Publishers; Springer Science+Business Media, 2002-07)
Magnetic Resonance Imaging of Ethyl-nitrosourea-induced Rat Gliomas: A Model for Experimental Therapeutics of Low-grade Gliomas
(Kluwer Academic Publishers; Springer Science+Business Media, 2001-07)
Human low-grade gliomas represent a population of brain tumors that remain a therapeutic challenge. Preclinical evaluation of agents, to test their preventive or therapeutic efficacy in these tumors, requires the use of ...
GREB1 is a critical regulator of hormone dependent breast cancer growth
(Kluwer Academic Publishers; Springer, 2005-07)
Background Estrogen plays a central role in breast cancer pathogenesis and many potent risk factors for the development of the disease can be explained in terms of increased lifetime exposure to estrogen. Although estrogen ...
Gamma-irradiation induces matrix metalloproteinase II expression in a p53-dependent manner
(John Wiley & Sons, Inc., 2000-04)
Matrix metalloproteinases (MMPs) are a family of proteinases that degrade the basement membrane and have been implicated in promoting tumor metastasis. MMP-2, one member of this family, was recently found to be a p53 target ...
p53 and its downstream proteins as molecular targets of cancer
(Wiley Subscription Services, Inc., A Wiley Company, 2006-06)
The p53 tumor suppressor gene plays a key role in prevention of tumor formation through transcriptional dependent and independent mechanisms. Transcriptional-dependent mechanisms are mainly mediated by p53 regulation of ...
The expression of RUNDC3B is associated with promoter methylation in lymphoid malignancies
(Wiley Periodicals, Inc.Springer, 2017-03)
DNA methylation is an epigenetic modification that plays an important role in the regulation of gene expression. The function of RUNDC3B has yet to be determined, although its dysregulated expression has been associated ...