Now showing items 111-120 of 999
Direct optical resolution of vesamicol and a series of benzovesamicol analogues by high-performance liquid chromatography
(Elsevier, 1994-04-29)
The direct optical resolution of the vesicular acetylcholine uptake inhibitors vesamicol and benzovesamicol and nine benzovesamicol analogues were performed by HPLC on a commercially available cellulose tris(3,5-dimethylphenyl ...
Iodine-promoted decomposition of 1-aryl-3,3-dialkyltriazenes: A mild method for the synthesis of aryl iodides
(Elsevier, 1994-08-01)
Iodine promoted decomposition of 1-aryl-3,3-dialkyltriazenes in organic solvents is shown to give high yields of the corresponding aryl iodides under extremely mild conditions. The presence of iodine greatly accelerates ...
Modulation of opioid signal transduction in SH-SY5Y neural cells by differentiating agents: Concurrent mu receptor upregulation and effector desensitization by phorbol ester
(Elsevier, 1994-02-21)
Long-term exposure of SH-SY5Y human neural cells to retinoic acid (RA) increased the binding of [3H]DAMGO and [3H]DPDPE by up to 3-fold compared to membranes of untreated cells. In contrast, incubation of the cells with ...
The interaction of artemisinin with malarial hemozoin
(Elsevier, 1994-01)
[14C]Artemisinin was taken up by Plasmodium falciparum in culture and concentrated in hemozoin. In vitro, hemin and artemisinin were found to undergo a chemical reaction forming two major products which were isolated by ...
Characterization of the genes encoding carbonic anhydrase I of chimpanzee and gorilla: comparative analysis of 5' flanking erythroid-specific promoter sequences
(Elsevier, 1993-09-15)
The genes encoding carbonic anhydrase I (CA I) have been characterized for chimpanzee (Pan troglodytes) and gorilla (Gorilla gorilla). In addition, 44 nucleotides (nt) at the 5' end of the noncoding first exon (exon la), ...
CSF somatostatin in Alzheimer's disease and major depression: Relationship to hypothalamic-pituitary-adrenal axis and clinical measures
(Elsevier, 1993)
Patients with Alzheimer's disease (AD) and major depression have been shown to have overlapping clinical symptoms and biological markers, including decreased concentrations of cerebrospinal fluid (CSF) somatostatin-like ...
Changes at multiple levels of the hypothalamo-pituitary adrenal axis following repeated electrically induced seizures
(Elsevier, 1990)
Seizures, including electrically induced seizures (ECS), activate the hypothalamo-pituitary-adrenal (HPA) axis in rats. The present studies were undertaken to characterize the effects of repeated ECS on hormone release and ...
Cultured adult rat jejunal explants as a model for studying regulation of CYP3A
(Elsevier, 1993-09-01)
Enzymes within the CYP3A subfamily are major Phase I drug-metabolizing enzymes present in hepatocytes and small bowel enterocytes. These enzymes are highly inducible in the liver by many structurally diverse compounds, ...