Now showing items 31-40 of 50
Combined autoradiographic-immunocytochemical analysis of opioid receptors and opioid peptide neuronal systems in brain
(Elsevier, 1985)
Using adjacent section autoradiography-immunocytochemistry, the distribution of [3H]naloxone binding sites was studied in relation to neuronal systems containing [Leu]enkephalin, dynorphin A, or [beta]-endorphin immunoreactivity ...
Changes in releasability of ACTH and Beta-endorphin with chronic stress
(Elsevier, 1985-02)
The activation of the hypothalamic pituitary adrenal axis by stress is well-known. Using inescapable intermittent footshock as a stressor in rats, we have previously demonstrated a rise in circulating plasma Beta-endorph ...
Distribution and regulation of the candidate prohormone processing enzymes SPC2 and SPC3 in adult rat brain
(Elsevier, 1994-12)
A number of candidate mammalian prohormone processing enzymes related to the yeast Kex2 endoprotease have been cloned and demonstrated to cleave several prohormone precursors at single, pairs and tetra basic amino acid ...
Prodynorphin-derived peptide expression in primate cortex and striatum
(Elsevier, 1994-11)
The distributions of four prodynorphin-derived peptides, dynorphin A (1-17), dynorphin A (1-8), dynorphin B, and [alpha]-neo-endorphin were determined in 10 cortical regions and the striatum of the old world monkey (Macaca ...
Characterization of pro-opiomelanocortin processing in heterologous neuronal cells that express PC2 mRNA
(Elsevier, 1993-05)
We have investigated processing of monkey pro-opiomelanocortin (POMC) following transfection into heterologous neuronal Neuro 2A (N2A) cells. In several separately transfected stable cell lines (termed N2A/POMC2-like; N = ...
Coupling an [alpha]2-Adrenergic receptor peptide to G-protein: A new photolabeling agent
(Elsevier, 1994)
A photoreactive derivative of a tetradecapeptide G-protein activator (peptide Q) derived from the [alpha]2-adrenergic receptor was designed and used to label purified G-protein (Go/Gi). N-bromoacetyl-N'-(3-diazopyruvoyl) ...
The degradation of dynorphin A in brain tissue in vivo and in vitro
(Elsevier, 1987)
The demonstration of analgesia following in vivo administration of dynorphin A (Dyn A) has been difficult. In contrast, a number of electrophysiological and behavioral effects reported with in vivo injection of Dyn A can ...
Further characterization of the extra-arcuate alpha-melanocyte stimulating hormone-like material in hypothalamus: Biochemical and anatomical studies
(Elsevier, 1986-04)
Previous studies had shown the existence of an extra-arcuate cell group in lateral hypothalamus which contains alpha-melanocyte stimulating hormone (a-MSH)-like immunoreactivity, but no other pro-opiomelanocortin (POMC) ...
Immunocytochemistry of the C-terminal peptide of propressophysin (CPP): Relationship to vasopressin, oxytocin and neurophysin
(Elsevier, 1983-07)
Arginine-vasopressin (AVP) and its associated neurophysin (AVP-NP) are synthesized via a precursor, propressophysin, which also contains a 39 amino acid glycopeptide at its C-terminus (C-terminus of propressophysin, or ...
Acute systemic administration of morphine selectively increases mu opioid receptor binding in the rat brain
(Elsevier, 1984-12)
Opioid receptor binding, including the mu, delta, and kappa receptor subtypes, was compared in morphine-injected and control rats. Brain tissues were homogenized and centrifuged either one or two times prior to receptor ...