Now showing items 21-30 of 209
Naloxone enhancement of DMT and LSD-25 induced suppression of food-rewarded bar pressing behavior in the rat
(Springer-Verlag, 1979-01)
The narcotic antagonist naloxone was tested to determine its possible interaction with N,N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) in adult male Holtzman rats trained to press a bar on a fixed-ratio ...
Contribution of social factors to opiate-induced activation in the mouse
(Elsevier, 1981-04)
Adult male Swiss-Webster mice of varying group size (single, or in groups of 2, 3, or 4) were injected with vehicle, or 25 or 50 mg/kg of morphine sulfate. In comparison with vehicle, morphine-injected mice showed heightened ...
Discriminative stimulus effects of pentobarbital in rhesus monkeys: Tests of stimulus generalization and duration of action
(Springer-Verlag, 1982-02)
Rhesus monkeys were trained to emit 20 or 30 consecutive responses on one lever following an IM injection of pentobarbital (10 or 18 mg/kg) and the same number of consecutive responses on another lever following an injection ...
GABA involvement in memory consolidation: Evidence from posttrial amino-oxyacetic acid
(Springer-Verlag, 1978-01)
In order to assess the possible effects of central GABA activation on the consolidation of shock avoidance, the GABA-T inhibitor amino-oxyacetic acid (AOAA) was administered posttrial to adult male rats. Learning was ...
Comparison of opioid agonists in maintaining responding and in suppressing morphine withdrawal in rhesus monkeys
(Springer-Verlag, 1981-09)
Sixteen opioid agonists were studied for their capacity both to maintain responding previously reinforced by codeine and to suppress the withdrawal syndrome induced by morphine deprivation in rhesus monkeys. All compounds, ...
Effects of trifluoperazine on the central nervous system of the cat
(Elsevier, 1966-01)
The effects of accumulative doses of trifluoperazine (0[middle dot]125-8 mg/kg) on the patellar and linguomandibular reflexes and segmentally evoked monosynaptic and polysynaptic spinal cord potentials were determined in ...
Effects of physostigmine on rat brain acetylcholine, acetylcholinesterase and conditioned pole jumping,
(Elsevier, 1968-03)
The present study was designed to provide evidence that the behavioral effects of physostigmine are related to inhibition of brain acetylcholinesterase (AChE). Adult male Holtzman rats were trained to pole jump to a buzzer ...
The reinforcing property of ethanol in the rhesus monkey
(Springer-Verlag, 1978-01)
Rhesus monkeys received intravenous injections of ethanol during daily sessions contingent on their presses on an available lever. Under the standard conditions, when each response on the lever during a 3-h period each day ...
Some thoughts on the relations between animal and human drug-taking
(Elsevier, 1983)
1. 1. Results of studies of drug self-administration have frequently been suggested as indicators of the potential for abuse of these drugs by humans. Historical data (pre 1970), although scant, supported this suggestion ...