Now showing items 11-20 of 1527
Substrate interaction defects in histidylâ tRNA synthetase linked to dominant axonal peripheral neuropathy
(University of WashingtonWiley Periodicals, Inc., 2018-03)
Histidylâ tRNA synthetase (HARS) ligates histidine to cognate tRNA molecules, which is required for protein translation. Mutations in HARS cause the dominant axonal peripheral neuropathy Charcotâ Marieâ Tooth disease ...
Chemical Reagents for Investigating the Major Groove of DNA
(Wiley Periodicals, Inc.Oxford University Press, 2001-07)
Chemical modification provides an inexpensive and rapid method for characterizing the structure of DNA and its association with drugs and proteins. Numerous conformation‐specific probes are available, but most investigations ...
Ontogenetic relationships between cranium and mandible in coyotes and hyenas
(Wiley Subscription Services, Inc., A Wiley Company, 2011-06)
Developing animals must resolve the conflicting demands of survival and growth, ensuring that they can function as infants or juveniles while developing toward their adult form. In the case of the mammalian skull, the ...
Improving on analyses of self-reported data in a large-scale health survey by using information from an examination-based survey
(John Wiley & Sons, Ltd., 2010-02-28)
Common data sources for assessing the health of a population of interest include large-scale surveys based on interviews that often pose questions requiring a self-report, such as, ‘Has a doctor or other health professional ...
Tests for gene-environment interaction from case-control data: a novel study of type I error, power and designs This article is a US government work, and, as such, is in the public domain in the United States of America.
(Wiley Subscription Services, Inc., A Wiley Company, 2008-11)
To evaluate the risk of a disease associated with the joint effects of genetic susceptibility and environmental exposures, epidemiologic researchers often test for non-multiplicative gene-environment effects from case-control ...
Synthesis of N2‐Substituted Deoxyguanosine Nucleosides from 2‐Fluoro‐6‐O‐(Trimethylsilylethyl)‐2′‐Deoxyinosine
(Wiley Periodicals, Inc.Aldrich Chemical Co., 2000-02)
Syntheses of N2‐substituted nucleosides have been studied for many years, primarily with ribonucleosides. However, the primary route to these compounds requires acidic conditions that are too vigorous for the acid‐labile ...
Conducting Randomized Trials in the Electrophysiology Laboratory: Lessons from a Randomized Comparison of Recording Methods During Pulmonary Vein Isolation by Segmental Ostial Ablation
(Kluwer Academic Publishers; Springer Science+Business Media, 2003-09)
Accurate identification of pulmonary vein (PV) potentials during segmental ostial ablation for PV isolation is very important to completely isolate the PVs and also to avoid unnecessary applications of radiofrequency energy. ...
Computational analysis of unassigned high-quality MS/MS spectra in proteomic data sets
(WILEY-VCH Verlag, 2010-07)
In a typical shotgun proteomics experiment, a significant number of high-quality MS/MS spectra remain “unassigned.” The main focus of this work is to improve our understanding of various sources of unassigned high-quality ...
Effect of Coadsorbed Water on Deep Oxidation Mechanisms: Temperature-Programmed Reactions of Benzene and Hydroxyl on the Pt(111) Surface
(Kluwer Academic Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2004-03)
The deep oxidation of benzene by preadsorbed hydroxyl on the Pt(111) surface has been characterized using temperature-programmed reaction spectroscopy. A mechanism for benzene oxidation in the presence of coadsorbed water ...