Now showing items 2821-2830 of 2832
Removing race and body surface area indexation for estimated kidney function based drug dosing: Aminoglycosides as justification of these principles
(Wiley Periodicals, Inc.Springer-Verlag, 2023-01)
Study ObjectiveThe use of race in medicine can contribute to health inequity. Updated equations for estimated glomerular filtration rate (eGFR) without race have been published. Likewise, de-indexation of eGFR to body ...
Internal medicine pharmacy residency programs: Residents’ pursuit of post-residency positions and job market perceptions
(John Wiley & Sons, Inc., 2023-02)
IntroductionPostgraduate year 2 (PGY2) internal medicine (IM) pharmacy residency programs have significantly grown over the past several years, and there is a perception that the IM clinical pharmacist job market is ...
Receptor Regulation of Osmolyte Homeostasis in Neural Cells in Response to Hyposmotic Stress.
(2010)
Cell swelling can have profound deleterious effects in the brain and is observed to occur during several pathological conditions. Upon swelling, cells regulate their volume through the extrusion of various osmolytes. ...
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update
(Wiley Periodicals, Inc., 2022-11)
Developing New STING-activating Metalloimmunotherapy
(2021)
Nutritional metal ions play critical roles in many important immune processes. Hence, effective modulation of metal ions may open up new forms of immunotherapy, termed as metalloimmunotherapy. The immunology studying how ...
Estimated glomerular filtration rate with and without race for drug dosing: Cystatin C vs. serum creatinine
(Wiley Periodicals, Inc., 2023-03)
Immuno-therapeutics Modulating B Immunity Against Cancer
(2024)
Vaccines activating B cell to mount robust antigen specific humoral immunity against foreign pathogens, like SARS-CoV-2 virus, influenza virus, human papillomavirus., have achieved tremendous clinical success. However, the ...
Evaluation of Lipid-Based Nanoparticles for the Treatment of Cardiovascular Diseases
(2024)
Nearly 17.9 million people die every year from cardiovascular-related diseases, which accounts for 31% of all deaths worldwide. Endogenous high-density lipoproteins (HDL) are natural cardioprotective particles that have ...
Home-based Therapeutic Drug Monitoring for Patient-Centric Precision Dosing of Immunosuppression after Solid Organ Transplantation
(2024)
The lifesaving potential of organ transplantation depends on the individualization of immunosuppressive drugs. Precision dosing is critical to prevent immune-mediated damage while minimizing toxicity. Precise dosing for ...
Machine Learning Guided Drug Discovery: Comprehensive Application in Janus Kinase Inhibitor Design
(2023)
Conventional drug discovery is often plagued by resource-intensive processes, leading to significant attrition rates due to challenges such as efficacy shortcomings, safety concerns and suboptimal pharmacokinetics (PK). ...