Now showing items 51-60 of 2837
Successfully Accelerating Translational Research at an Academic Medical Center: The University of Michigan-Coulter Translational Research Partnership Program
(Blackwell Publishing Inc, 2010-12)
Translational research encompasses the effective movement of new knowledge and discoveries into new approaches for prevention, diagnosis, and treatment of disease. There are many roadblocks to successful bench to bedside ...
Pharmacokinetics and pharmacodynamics of pirmenol enantiomers in coronary artery ligated dogs
(John Wiley & Sons, Inc., 1997-04)
The pharmacokinetics and pharmacodynamics of pirmenol enantiomers were investigated in coronary artery ligated mongrel dogs. Reduction in frequency of premature ventricular complexes (PVCs) was determined following intravenous ...
Improved Targeting and Biopharmaceutical Properties of Prodrugs of Anti-infective Agents.
(2013)
The prodrug strategy has been frequently used as a chemical approach for the enhancement of certain disadvantages of parent drugs. In this dissertation, I synthesized prodrugs of two anti-infective agents, ganciclovir and ...
Drug‐like Leads for Steric Discrimination between Substrate and Inhibitors of Human Acetylcholinesterase
(Blackwell Publishing LtdWiley Periodicals, Inc., 2011-10)
Drug Marker Absorption in Relation to Pellet Size, Gastric Motility and Viscous Meals in Humans
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1998-02)
Purpose . The objective of this study was to evaluate drug marker absorption in relation to the gastric emptying (GE) of 0.7 mm and 3.6 mm enteric coated pellets as a function of viscosity and the underlying gastric motility.
Human Jejunal Permeability of Two Polar Drugs: Cimetidine and Ranitidine
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2001-06)
Purpose . To determine the human jejunal permeability of cimetidine and ranitidine using a regional jejunal perfusion approach, and to integrate such determinations with previous efforts to establish a baseline correlation ...
Biopharmaceutics Classification System: The Scientific Basis for Biowaiver Extensions
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2002-07)
Allostery at opioid receptors: modulation with small molecule ligands
(John Wiley & Sons, Ltd, 2018-07)
Intrathecal morphine slows gastrointestinal transit in rats
(Elsevier, 1985-12-17)
Intrathecal (i.th.) (by direct lumbar puncture) and intraperitoneal (i.p.) administration of morphine (30-100 [mu]g/rat) caused a dose-related inhibition of gastrointestinal transit in the rat. Pretreatment with i.th. ...