Now showing items 31-40 of 67
The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats
(Springer-Verlag, 2005-07)
Exposure to extreme stress has been suggested to produce long-term, detrimental alterations in the hypothalamic–pituitary–adrenal (HPA) axis leading to the development of mental disorders such as depression. Therefore, ...
Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients
(Blackwell Science Pty, 2003-10)
Alcohol-dependent outpatients with persisting insomnia were treated with either gabapentin or trazodone. Patients were assessed at baseline and after 4–6 weeks on medication using the Sleep Problems Questionnaire (SPQ). ...
Differential effects of nicotine on alcohol consumption in men and women
(Springer-Verlag, 2006-05)
Nicotine and alcohol are frequently co-used, suggesting that use of one drug may facilitate use of the other. Furthermore, because men and women differ in their responses to both drugs, it is possible that men and women ...
Methoclocinnamox: time course of changes in alfentanil-reinforced responding in rhesus monkeys
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2000-03)
Rationale : Methoclocinnamox (MC-CAM) possesses initial partial µ-opioid agonist activity with subsequent long-lasting µ-antagonist effects. This profile of activity is similar to that of buprenorphine, a compound with ...
Desipramine attenuates working memory impairments induced by partial loss of catecholamines in the rat medial prefrontal cortex
(Springer-Verlag, 2006-01)
The density of tyrosine hydroxylase-immunoreactive (TH-IR) axons in the prefrontal cortex of schizophrenic subjects may be reduced by as much as 50% in the deep cortical layers (Am J Psychiatry 156:1580–1589, 1999). ...
Determinants of the behavioral effects of opioids and their antagonists: contributions of the Laboratory of Psychobiology
(Springer-Verlag, 2002-10)
Abstract
Social defeat alters the acquisition of cocaine self-administration in rats: role of individual differences in cocaine-taking behavior
(Springer-Verlag, 2001-12)
Rationale : It is known that social defeat can modulate cocaine self-administration. However, it is unclear whether this psychosocial stressor affects drug-taking behavior to the same extent across all individual animals, ...
Environmental modulation of the response to amphetamine: dissociation between changes in behavior and changes in dopamine and glutamate overflow in the rat striatal complex
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2000-08)
Rationale: We have previously shown that environmental novelty enhances the behavioral activating effects of amphetamine and amphetamine-induced expression of the immediate early gene c- fos in the striatal complex, ...
A statistical approach for classifying change in cognitive function in individuals following pharmacologic challenge: an example with alprazolam
(Springer-Verlag, 2006-05)
The effects of any drug treatment on cognitive function are typically studied in groups of subjects. Observations made about the behavior of the drug, in the study sample, are then generalized to the population from which ...
Food addiction and impaired executive functions in women with obesity
(American Psychiatric AssociationWiley Periodicals, Inc., 2018-11)
BackgroundIndividuals with obesity (OB) often report suffering from addictionâ like symptoms. As in addictions, deficits in executive function domains, such as decisionâ making and sustained attention, are found in OB. ...