Now showing items 71-80 of 209
Discriminative and reinforcing effects of brotizolam in rhesus monkeys
(Springer-Verlag, 1991-02)
The reinforcing and discriminative stimulus effects of brotizolam, a benzodiazepine-hypnotic, were evaluated in rhesus monkeys. In one experiment, separate groups of monkeys ( N =3/group) were trained to discriminate ...
Quadazocine decreases responding reinforced by ethanol, sucrose, and phencyclidine fluid deliveries in rhesus monkeys: comparison to naltrexone’s effects
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-06)
Rationale: The endogenous opioid system may mediate the reinforcing effects of ethanol as well as sweet-tasting solutions. For example, opioid antagonists, such as naltrexone, reduce ethanol- and sucrose-reinforced ...
Chronic treatment with ethanol produces supersensitivity to oxotremorine
(Elsevier, 1990)
1. The effect of chronic treatment with ethanol (14% v:v in drinking water) on the physiological endpoint core temperature which is partially regulated by a muscarinic mechanism was measured in adult male rats (n = 8).2. ...
Fever and leukocytosis: Physical manifestations of bipolar affective disorder?
(Elsevier, 1988)
1. 1. Fever and leukocytosis are occasionally observed in patients with psychiatric disorders. A thorough medical evaluation does not always reveal the origin of these abnormalities.2. 2. We report the case histories of ...
Changes in locomotor activity and naloxone-induced jumping in mice produced by WIN 35,197-2 (Ethylketazocine) and morphine
(Springer-Verlag, 1978-01)
Acute i.p. administration of morphine or cocaine produced increase in locomotor activity in Swiss-Webster female mice that were maximal at 32–100 mg/kg for morphine and at 32 mg/kg for cocaine. WIN 35,197-2 produced ...
Aggression, anxiety and vocalizations in animals: GABA A and 5-HT anxiolytics
(Springer-Verlag, 1995-09)
A continuing challenge for preclinical research on anxiolytic drugs is to capture the affective dimension that characterizes anxiety and aggression, either in their adaptive forms or when they become of clinical concern. ...
Effects of N,N-dimethyltryptamine on electrically evoked responses in the cat visual system and modification by neuroleptic agents,
(Elsevier, 1976-09)
The effects of N,N-dimethyltryptamine on electrically evoked potentials in the visual system of the cat and the interaction of selected neuroleptic agents with dimethyltryptamine were studied. Dimethyltryptamine caused a ...
Serotonin synthesis inhibition reveals distinct mechanisms of action for MDMA and its enantiomers in the mouse
(Springer-Verlag, 2005-09)
Drug challenges in “intact” and p -chlorophenylalanine ( p -CPA)-treated animals can be used to distinguish agents that act as direct serotonin (5-HT) agonists from agents that function as 5-HT releasers.
Platelet alpha2 adrenoreceptors are decreased in number after antidepressant therapy
(Elsevier, 1983)
1. 1. Specific binding of 3H-clonidine to alpha2 adrenoreceptors upon human blood platelet membranes is increased in patients with major depressive disorder (endogenous depression).2. 2. Specific binding of 3H-yohimbine ...
Self-administration of fentanyl, cocaine and ketamine: effects on the pituitary–adrenal axis in rhesus monkeys
(Springer-Verlag, 2004-11)
Drugs of abuse can affect the functioning of the hypothalamic–pituitary–adrenal (HPA) axis. Acute administration of drugs that serve as reinforcers have been observed to stimulate the rat HPA axis, leading to the suggestion ...