Now showing items 91-100 of 666
Glycine Protection of PC-12 Cells Against Injury by ATP-Depletion
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2003-06)
A distinctive mechanism of cell injury during ATP depletion involves the loss of cellular glycine. The current study examined whether provision of glycine during ATP depletion can prevent injury in PC-12 cells, a cell line ...
Cell line dependent involvement of ceramide in ultraviolet light-induced apoptosis
(Kluwer Academic Publishers; Springer Science+Business Media, 2001-03)
Ultraviolet light (UV) activates an acid sphingomyelinase (ASMase) pathway, which hydrolyzes sphingomyeline to ceramide. Ceramide has been found to be a second messenger, which activates the c-jun N-terminal kinase (JNK) ...
Modelling tumour biology–progression relationships in screening trials
(John Wiley & Sons, Ltd., 2005)
There has been some recent work in the statistical literature for modelling the relationship between tumour biology properties and tumour progression in screening trials. While non-parametric methods have been proposed for ...
Aged B cells alter immune regulation of allografts in mice
(Wiley Periodicals, Inc., 2016-11)
Confidence intervals of effect size in randomized comparative parallel-group studies
(John Wiley & Sons, Ltd., 2006-02-28)
We have presented a new likelihood-based approach for constructing confidence intervals of effect size that are applicable to small samples. We also conduct a simulation study to compare the coverage probability of the new ...
Characterization of Tertiary Folding of RNA by Circular Dichroism and Urea
(Wiley Periodicals, Inc., 2001-04)
CD spectroscopy can be used to monitor RNA tertiary folding transitions that may not be observable by absorbance spectroscopy. With the use of computer‐controlled titrators, data can be acquired rapidly, and accurate ...
Biophysical Analysis of Nucleic Acids
(VCH PublishersWiley Periodicals, Inc., 2000-02)
This overview unit provides a thorough overview of biophysical methods used for structure analysis, including X‐ray diffraction, nuclear magnetic resonance, optical spectroscopy, theoretical and computational methods, and ...
Induction of adaptive immunity by flagellin does not require robust activation of innate immunity
(WILEY-VCH Verlag, 2009-02)
The ability of TLR agonists to promote adaptive immune responses is attributed to their ability to robustly activate innate immunity. However, it has been observed that, for adjuvants in actual use in research and vaccination, ...
Models of HPV as an Infectious Disease and as an Etiological Agent of Cancer.
(2015)
The human papillomavirus (HPV) infects multiple sites in the human epithelium and is the etiological agent for over 90% of anogenital cancers and an increasing percentage of oropharyngeal cancers. HPV presents an inherently ...