Now showing items 41-50 of 811
Determination of Binding Mode: Intercalation
(Academic PressWiley Periodicals, Inc., 2000-02)
A small molecule can be assumed to bind to DNA by intercalation between base pairs if it causes lengthening and unwinding of the DNA helix and undergoes changes in its spectral properties, such as DNA‐induced hypochromism ...
Cellular Delivery of Locked Nucleic Acids (LNAs)
(Wiley Periodicals, Inc., 2002-06)
Locked nucleic acids (LNAs) are RNA derivatives that have an O‐methylene linkage between the 2 and 4 positions of the ribose. This leads to exceptionally high‐affinity binding to complementary sequences. They are synthesized ...
Separation of bile acids from neutral lipids on thin-layer chromatograms
(Elsevier, 1974-11-13)
Development of hypothalamic opioid neurons: A combined immunocytochemical and [3H]thymidine autoradiographic study
(Elsevier, 1985-02)
Using a combined technique of immunocytochemistry and [3H]thymidine autoradiography, we have determined the "birth-date" of opioid peptide containing neurons in three hypothalamic nuclei. These include proopiomelanocortin ...
Immunohistochemical localization of the mu opioid receptors
(Elsevier, 1994-11-10)
Using antibodies generated to the C-terminal 63 amino acids of the cloned rat mu receptor, the present study examines the distribution of the mu receptor-like immunoreactivity (li) in perfused rat brain sections. Generally, ...
A game to help students comprehend enzyme structure and mechanism of action
(Elsevier, 1976-01)
A specific radioimmunoassay for androstenedione with reduced bridge-binding
(Elsevier, 1984-09)
Antibody used in a steroid radioimmunoassay raised against a steroid hapten-carrier protein conjugate may recognize both the hapten and the chemical bridge to the protein. Use of the same bridge in the radioisotopic label ...
Effects of serum and insulin-like growth factors on human neuroblastoma cell growth
(Elsevier, 1993-10-20)
Insulin-like growth factors (IGF-I and IGF-II) are mitogenic polypeptides expressed in both developing and adult tissues. To examine the effects of IGFs on neuronal growth, we used SH-SY5Y neuroblastoma cells as an in vitro ...
Metabolism of triphenylmethane and triphenylcarbinol
(Elsevier, 1964-08)
A study of the metabolism of triphenylmethane and triphenylcarbinol in the rabbit indicates that the major urinary metabolite of these two compounds is the corresponding glucuronide. When 1 gm of triphenylmethane is fed ...
Clocinnamox blocks only mu receptors irreversibly: Binding evidence
(Elsevier, 1994-11-10)