Now showing items 21-30 of 54
Interaction between gemcitabine and mitomycin-C in vitro
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2000-01)
Both gemcitabine (2′,2′-difluorodeoxycytidine; dFdCyd) and mitomycin-C (MMC) are active against several solid malignancies. dFdCyd is an attractive agent for use in combination with drugs which damage DNA and with radiation ...
Hepatic arterial chemotherapy for primary and metastatic liver cancers
(Springer-Verlag, 1989-01)
Hepatic arterial chemotherapy represents a means of selectively exposing hepatic tumor to cytotoxic agents. Although 5-fluoro-2′-deoxyuridine has been shown to generate a higher response rate in the treatment of colorectal ...
Response of human HT-29 colorectal tumor cells to extended exposure to bromodeoxyuridine
(Springer-Verlag, 1989-01)
Effects of the extended exposure of a human colorectal tumor-cell line (HT-29) to bromodeoxyuridine (BrdUrd) were studied in anticipation of the clinical use of that agent to treat colorectal cancer, particularly as a ...
Pharmacologic studies on the dibutyl and γ-monobutyl esters of methotrexate in the rhesus monkey
(Springer-Verlag, 1982-12)
The pharmacokinetics and metabolism of dibutyl methotrexate (DBMTX) and γ-monobutyl methotrexate (γ-MBMTX) were studied in Rhesus monkeys. When a bolus IV dose of either [ 3 H]DBMTX or [ 3 H]γ-MBMTX was given, the principal ...
A Phase II Trial of Pyrazine Diazohydroxide in Patients with Disseminated Malignant Melanoma and no Prior Chemotherapy – Southwest Oncology Group Study
(Kluwer Academic Publishers; Springer Science+Business Media, 2002-02)
Malignant melanoma is rapidly increasing inthe United States. Metastatic diseaseresponds poorly to currently availablechemotherapy. Pyrazine diazohydroxide(PZDH) is a new agent inhibiting DNAsynthesis that is active in ...
Phase II trial of N-methylformamide in lung cancer
(Kluwer Academic Publishers; Springer Science+Business Media, 1992-08)
Phase II trial of methylglyoxal bis-guanylhydrazone (MGBG) in refractory small cell lung cancer
(Kluwer Academic Publishers; Springer Science+Business Media, 1990-03)
Methylglyoxal bis-guanylhydrazone (MGBG), a potent inhibitor of polyamine synthesis, has demonstrated single agent activity against a number of tumor types including malignant lymphomas and head and neck, esophageal and ...
Phase II study of oral bis (aceto) ammine dichloro (cyclohexamine) platinum (IV) (JM-216, BMS-182751) given daily x 5 in hormone refractory prostate cancer (HRPC)
(Kluwer Academic Publishers; Springer Science+Business Media, 2005-01)
JM-216 is an orally bioavailable platinum compound with activity against many tumor models. The objective of this study was to determine the safety profile and anti-tumor activity of JM-216 in patients with hormone refractory ...
Evaluation of merbarone (NSC 336628) in disseminated malignant melanoma
(Kluwer Academic Publishers; Springer Science+Business Media, 1995-06)
Merbarone, NSC 336628, is an investigational anticancer drug with activity against experimental animal tumors including melanoma. This paper presents results of a Phase II clinical study of merbarone in patients with biopsy ...
VM-26 in colorectal carcinoma: A Southwest Oncology Group study
(Kluwer Academic Publishers; Springer Science+Business Media, 1990-02)
In this multi-institutional phase II study, VM-26 or Teniposide was administered to forty-two patients with advanced colorectal cancer. Patients were initially treated at 60 mg/M 2 daily for 5 days with dose adjustments ...