Now showing items 21-30 of 32
The role of DNA synthesis inhibition in the cytotoxicity of 2′,2′-difluoro-2′-deoxycytidine
(Springer-Verlag, 2003-10)
Cytotoxicity from the anticancer drug 2′,2′-difluoro-2′-deoxycytidine (dFdCyd) has been correlated with its incorporation into DNA. However, cytotoxicity may also result from inhibition of DNA synthesis, due to either (1) ...
Phase II trial of fenretinide in advanced renal carcinoma
(Kluwer Academic Publishers; Springer Science + Business Media, Inc., 2005-01)
Purpose : Fenretinide, a synthetic form of retinoid, induced apoptosis even in chemotherapy resistant cell lines. A phase II study was hence conducted to evaluate toxicity and efficacy of fenretinide in metastatic renal ...
A self-renewal assay for cancer stem cells
(Springer-Verlag, 2005-11)
Cancers of epithelial origin are responsible for the majority of cancer-related deaths in the USA. Unfortunately, although chemotherapy and/or radiation therapy can sometimes shrink tumors, metastatic cancers of epithelial ...
A phase II study of chloroquinoxaline sulfonamide (CQS) in patients with metastatic colorectal carcinoma (MCRC)
(Kluwer Academic Publishers; Springer Science + Business Media, Inc, 2006-01-28)
Purpose: Phase II multicenter study investigated the efficacy and toxicity of the novel halogenated derivative of sulfaquixonaline Chloroquinoxaline Sulfonamide (CQS) in metastatic colorectal cancer. Experimental design: ...
Novel Models to Image and Quantify Bone Drug Efficacy and Disease Progression In Vivo: Addressing the Fragility Phenotype
(2019)
Bone is a composite biomaterial of mineral crystals, organic matrix, and water. Each contributes to bone quality and strength and may change independently, or together, with disease progression and treatment. Even so, there ...
Computer Simulation of a Nitric Oxide-Releasing Catheter with a Novel Stable Convection-Diffusion Equation Solver and Automatic Quantification of Lung Ultrasound Comets by Machine Learning
(2020)
Biological transport processes often involve a boundary acting as separation of flow, most commonly in transport involving blood-contacting medical devices. The separation of flow creates two different scenarios of mass ...
Label Uncertainty and Learning Using Partially Available Privileged Information for Clinical Decision Support: Applications in Detection of Acute Respiratory Distress Syndrome
(2021)
Artificial intelligence and machine learning have the potential to transform health care by deriving new and important insights from the vast amount of data generated during routine delivery of healthcare. The digitization ...
Quantitative Image Reconstruction Methods for Low Signal-To-Noise Ratio Emission Tomography
(2020)
Novel internal radionuclide therapies such as radioembolization (RE) with Y-90 loaded microspheres and targeted therapies labeled with Lu-177 offer a unique promise for personalized treatment of cancer because imaging-based ...
Advances in Quantitative MRI: Acquisition, Estimation, and Application
(2018)
Quantitative magnetic resonance imaging (QMRI) produces images of potential MR biomarkers: measurable tissue properties related to physiological processes that characterize the onset and progression of specific disorders. ...
Isolation and Characterization of Circulating Biomarkers to Predict Patient Outcomes in Late-Stage Non-Small Cell Lung Cancer
(2021)
This work hypothesizes that the molecular characterization of extracellular vesicles (EVs) and circulating tumor cells (CTCs), biomarkers found in peripheral blood draws, can be used to monitor, and predict, treatment ...