Now showing items 31-40 of 894
Early events of Bacillus anthracis germination identified by time-course quantitative proteomics
(WILEY-VCH Verlag, 2006-10)
Germination of Bacillus anthracis spores involves rehydration of the spore interior and rapid degradation of several of the protective layers, including the spore coat. Here, we examine the temporal changes that occur ...
Cellular Delivery of Locked Nucleic Acids (LNAs)
(Wiley Periodicals, Inc., 2002-06)
Locked nucleic acids (LNAs) are RNA derivatives that have an O‐methylene linkage between the 2 and 4 positions of the ribose. This leads to exceptionally high‐affinity binding to complementary sequences. They are synthesized ...
A false-discovery-rate-based loss framework for selection of interactions
(John Wiley & Sons, Ltd., 2008-05-20)
Interaction effects have been consistently found important in explaining the variation in outcomes in many scientific research fields. Yet, in practice, variable selection including interactions is complicated due to the ...
Visualization of Protein Interactions in Living Cells Using Bimolecular Fluorescence Complementation (BiFC) Analysis
(Wiley Periodicals, Inc., 2005-12)
Protein interactions integrate stimuli from different signaling pathways and developmental programs. Bimolecular fluorescence complementation (BiFC) analysis has been developed for visualization of protein interactions in ...
Use of inverse PCR to amplify and sequence breakpoints of HPRT deletion and translocation mutations
(John Wiley & Sons, Inc., 2002)
Deletion and translocation mutations have been shown to play a significant role in the genesis of many cancers. The hprt gene located at Xq26 is a frequently used marker gene in human mutational studies. In an attempt ...
Non-parametric estimation of gap time survival functions for ordered multivariate failure time data
(John Wiley & Sons, Ltd., 2004-06-30)
Times between sequentially ordered events (gap times) are often of interest in biomedical studies. For example, in a cancer study, the gap times from incidence-to-remission and remission-to-recurrence may be examined. Such ...
Ventral hippocampal muscimol disrupts context-specific fear memory retrieval after extinction in rats
(Wiley Subscription Services, Inc., A Wiley Company, 2006-02)
Research aimed at understanding Pavlovian fear memory extinction has yielded considerable insight into the conditions under which fear memories may become inhibited. After extinction, Pavlovian fear memory retrieval is ...
The murine CC chemokine, 6C-kine, inhibits tumor growth and angiogenesis in a human lung cancer SCID mouse model
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2001-01)
The recently described CC chemokine, 6C-kine, is unique in that it contains -six rather than the usual four conserved cysteines typical of this family. Furthermore, murine 6C-kine binds to one of the CXC chemokine receptors ...
Prevention of visual stress and migraine with precision spectral filters
(Wiley Subscription Services, Inc., A Wiley Company, 2007-11)
Individuals who suffer migraine, particularly migraine with visual aura (MwA), are susceptible to physiologically strong visual stimuli and find them aversive. Strong stimuli including bright light and certain visual ...