Now showing items 1911-1920 of 1943
Roles of the Unfolded Protein Response in Cultured Cells and Transgenic Murine Models.
(2007)
When protein folding in the endoplasmic reticulum(ER) is disrupted by alterations in homeostasis in the ER lumen, eukaryotic cells activate a series of signal transduction cascades that are collectively termed the Unfolded ...
Cell Specific Regulation of Sonic Hedgehog in Adult Stomach: Understanding Mechanisms Leading to Gastric Atrophy/Metaplasia. Mechanisms Leading to Gastric Atrophy/Metaplasia.
(2009)
Helicobacter induced gastritis of the corpus results in loss of parietal cell function, loss of the oxyntic gland (atrophy), changes that predispose to gastric cancer. The molecular details of how chronic inflammation in ...
The Role of Sulfenic Acid Modification in the Regulation of the Cardiovascular Voltage-Gated Potassium Channel, Kv1.5.
(2011)
Atrial fibrillation, the most common cardiac arrhythmia in the United States, is a significant cause of morbidity and mortality. Environmental exposures such as cigarette smoking, as well as pre-existing cardiovascular ...
Regulation of Bone Formation and Pathology by Local Actions of Leptin in the Bone Marrow.
(2011)
Site-specific adipose content of the bone marrow has been noted since the inclusion
of meat into the hominid diet, evidenced by marrow removal from ungulate limb
bones, 2.6 million years ago. Association between marrow fat ...
The Effects and Genetic Mechanisms of Bacterial Species Interactions on Biofilm Formation.
(2010)
Bacteria can increase their survival in stressed environments by forming sessile biofilms on surfaces. Natural ecosystems are usually occupied by multiple species, which may interact with and therefore affect biofilm ...
Role of CHD7 in Neural Development and Maintenance.
(2011)
Normal tissue development and maintenance require precise timing and correct localization of gene expression. Several lines of evidence indicate that the chromodomain (CHD) family of proteins are critical regulators of ...
Hypocretin-1 and GABA in the Pontine Reticular Formation Interact to Promote Wakefulness.
(2010)
Hypocretin-1 and hypocretin-2 are wake-promoting neuropeptides that are exclusively synthesized in the lateral hypothalamus. Hypocretin deficiency underlies the sleep disorder narcolepsy, which is characterized by excessive ...
Bioinformatic Analysis of Epithelial:Mesenchymal Crosstalk during Mouse Gut Development and Patterning
(2009)
ABSTRACT
BIOINFORMATIC ANALYSIS OF EPITHELIAL:MESENCHYMAL CROSSTALK DURING MOUSE GUT DEVELOPMENT AND PATTERNING
By
Xing Li
Chair: Deborah L. Gumucio
The small intestine develops from a tube of endoderm wrapped by ...
Thermodynamic and Kinetic Parameters that Explain Crystallization and Solubility of Pharmaceutical Cocyrstals.
(2009)
Cocrystals have emerged as a viable alternative to increase the diversity of solid-state drug forms. Literature surrounding cocrystals range from design using crystal engineering principles to evaluating the pharmaceutical ...
Memory, Interference and Depression.
(2010)
This dissertation explores the role of interference in short-term memory and how interference in memory may influence depression. The first chapter tackles whether forgetting in the short-term is due to decay with the ...