Now showing items 1921-1930 of 1943
Fast Capillary Electrophoresis for the Study of Dopamine in the Central Nervous System.
(2011)
The study of neurochemical events in the central nervous system (CNS) with temporal resolution ranging from seconds to minutes facilitates the evaluation of intercellular communication on times scales that are relevant to ...
Exploiting the Bioenergetics of Disease-Causing Lymphocytes for Selective Immunomodulation.
(2012)
In diseases such as lupus or graft-versus-host disease (GVHD), lymphocytes react against self- or allo-antigen and mediate tissue damage. Current treatments for such diseases rely on non-specific immunosuppression and ...
A Subcellular Compartmental Modeling Approach to Pulmonary Drug Development.
(2011)
Predicting and controlling the systemic and local pharmacokinetics of pulmonary medications in different regions of the lung is critical for optimizing the efficacy and safety of inhaled drugs. Here, a modular, multiscale, ...
Multi-Continental Multimedia Model of Pollutant Intake and Application to Impacts of Global Emissions and Globally Traded Goods.
(2011)
Decision-makers seeking to more comprehensively assess and mitigate the environmental health impacts of products and chemicals require a tool to quantify the impacts associated with global emissions, global supply chains, ...
A Gene-environment Study of Metallothionein Single Nucleotide Polymorphisms, Mercury Biomarker Levels and Peripheral Nerve Function.
(2011)
Mercury (Hg) is a potent neurotoxicant. Recent studies have suggested that several genes that mediate mercury metabolism are polymorphic in humans. We hypothesized that single nucleotide polymorphisms (SNPs) in metallothionein ...
Multiple Imputation for Measurement Error Correction Based on a Calibration Sample.
(2010)
In much of applied statistics variables of interest are measured with error. In particular, regression with covariates that are subject to measurement error requires adjustment to avoid biased estimates and invalid inference. ...
Cheminformatic and Mechanistic Study of Drug Subcellular Transport/Distribution.
(2011)
The subcellular transport and distribution behavior determines both the pharmacological effect on the cellular level and the drug exposure at a tissue, organ and whole body level. Despite of the rapid evolution in experimental ...
Pubertal hormones alter circadian timekeeping: Evidence from two rodent models, Rattus norvegicus and Octodon degus.
(2010)
There is overwhelming evidence that the circadian timekeeping system is sensitive to gonadal hormones during perinatal development and adulthood. However, there is a noticeable lack of research in animal models focusing ...
Thiol-Mediated Redox Modulation of the Adaptive Immune Response.
(2010)
T cell activation and proliferation requires a reducing microenvironment that is provided by antigen presenting cells especially dendritic cells (DCs). Naturally occurring CD4+CD25+Foxp3+ regulatory T cells (Tregs) suppress ...
Structure Based Design of Peptidomimetic Inhibitors of the MLL1-WDR5 Interaction.
(2012)
MLL1 is a histone-3 lysine-4 (H3K4) methyltransferase, which is misregulated in patients with leukemia and linked with tumorigenicity through upregulation of the target genes HoxA9 and Meis-1. Suppressing expression of ...