Now showing items 831-840 of 843
Multiple Imputation for Measurement Error Correction Based on a Calibration Sample.
(2010)
In much of applied statistics variables of interest are measured with error. In particular, regression with covariates that are subject to measurement error requires adjustment to avoid biased estimates and invalid inference. ...
Cheminformatic and Mechanistic Study of Drug Subcellular Transport/Distribution.
(2011)
The subcellular transport and distribution behavior determines both the pharmacological effect on the cellular level and the drug exposure at a tissue, organ and whole body level. Despite of the rapid evolution in experimental ...
Pubertal hormones alter circadian timekeeping: Evidence from two rodent models, Rattus norvegicus and Octodon degus.
(2010)
There is overwhelming evidence that the circadian timekeeping system is sensitive to gonadal hormones during perinatal development and adulthood. However, there is a noticeable lack of research in animal models focusing ...
Thiol-Mediated Redox Modulation of the Adaptive Immune Response.
(2010)
T cell activation and proliferation requires a reducing microenvironment that is provided by antigen presenting cells especially dendritic cells (DCs). Naturally occurring CD4+CD25+Foxp3+ regulatory T cells (Tregs) suppress ...
Structure Based Design of Peptidomimetic Inhibitors of the MLL1-WDR5 Interaction.
(2012)
MLL1 is a histone-3 lysine-4 (H3K4) methyltransferase, which is misregulated in patients with leukemia and linked with tumorigenicity through upregulation of the target genes HoxA9 and Meis-1. Suppressing expression of ...
Unraveling Novel Leptin-Dependent Signaling Pathways in the Basomedial Hypothalamus.
(2010)
Leptin is secreted by the adipose tissue in proportion to fat stores and acts on the hypothalamus to inhibit appetite and promote energy expenditure. Leptin also regulates glucose homeostasis independently of feeding, and ...
Regulating Gene Expression Through DNA Mechanics: Tightly Looped DNA Represses Transcription.
(2010)
It is now widely accepted that the mechanical state of DNA can play a major role in regulating the activity of RNA polymerase (RNAP). Not only have the global levels of supercoiling been shown to regulate transcription, ...
Linkages Between Extreme Precipitation, Water Quality, and Gastrointestinal Illness.
(2012)
Background: The frequency, intensity, and duration of extreme weather events are expected to increase based on current climate model projections. Such changes, particularly those associated with extreme precipitation, will ...
Defining the Role of Yersinia pestis Ail in Host Cell Interactions and Plague Virulence Functions.
(2011)
Adhesion to host cells and delivery of cytotoxic Yops are essential steps in the infection process of the plague pathogen Yersinia pestis. The Y. pestis adhesin Ail was recently demonstrated to mediate host cell binding ...
The Landscape of C. elegans 3'UTRs.
(2011)
The 3’ untranslated regions (3’UTRs) of mRNAs have recently been shown to play major roles in gene regulation by interaction with small (21-26nt length) RNAs, such as microRNAs and small interfering RNAs (siRNAs). Recent ...