Now showing items 51-60 of 177
On the Need to Develop Guidelines for Characterizing and Reporting Intrinsic Disorder in Proteins
(BIPM, SevresWiley Periodicals, Inc., 2019-03)
Since the early 2000s, numerous computational tools have been created and used to predict intrinsic disorder in proteins. At present, the output from these algorithms is difficult to interpret in the absence of standards ...
Differentially Degradable Janus Particles for Controlled Release Applications
(WILEY‐VCH Verlag, 2012-07-26)
Janus particles with differentially degradable compartments were prepared by electrohydrodynamic (EHD) co‐jetting and subsequent controlled crosslinking. These bicompartmental particles are composed of an interpenetrating ...
Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5
(WILEY-VCH Verlag, 2011-04)
Affinity purification coupled to mass spectrometry (AP-MS) represents a powerful and proven approach for the analysis of protein–protein interactions. However, the detection of true interactions for proteins that are ...
Dose‐dependent proteomic analysis of glioblastoma cancer stem cells upon treatment with γ‐secretase inhibitor
(WILEY‐VCH Verlag, 2011-12)
Notch signaling has been demonstrated to have a central role in glioblastoma (GBM) cancer stem cells (CSCs) and we have demonstrated recently that Notch pathway blockade by γ‐secretase inhibitor (GSI) depletes GBM CSCs and ...
Selectivity Enhancement for Chloride Ion by In(III)‐Porphyrin‐Based Polymeric Membrane Electrode Operated in Pulsed Chronopotentiometric Mode
(WILEY‐VCH Verlag, 2012-03)
A robust selectivity enhancement of an In(III)‐porphyrin ionophore‐based chloride‐selective electrode under pulsed chronopotentiometric measurement mode that enables the detection of chloride ions in the presence of a ...
How microbial proteomics got started
(WILEY‐VCH Verlag, 2011-08)
Publication in 1975 by Patrick O'Farrell of a procedure to separate the proteins of Escherichia coli in a two‐dimensional array on polyacrylamide gels marked the birth of the field now called proteomics. Although O'Farrell's ...
Protease‐Sensitive PEG Hydrogels Regulate Vascularization In Vitro and In Vivo
(Wiley Periodicals, Inc., 2014-10)
Forming functional blood vessel networks in engineered or ischemic tissues is a significant scientific and clinical hurdle. Poly(ethylene glycol) (PEG)‐based hydrogels are adapted to investigate the role of mechanical ...
Vibrational Probe and Methods Development for Studying the Ultrafast Dynamics of Preferential Solvation of Biomolecules by 2D-IR.
(2015)
Over the last decade two-dimensional infrared spectroscopy (2D-IR) has emerged as a powerful method for the investigation of biological samples and their dynamics. Through the implementation of state of the art signal ...