Now showing items 91-100 of 152
Model studies of lantibiotic biogenesis
(Elsevier, 1993-12-03)
A six residue polypeptide has been synthesized to study the proposed biosynthesis of lanthionine. It is shown that this peptide spontaneously cyclizes in a biomimetic fashion via a completely stereoselective intramolecular ...
Centrally administered [mu]- and [delta]-opioid agonists increase operant responding for saccharin
(Elsevier, 1993-08)
In previous reports, ICV administration of selective [mu]- or [delta]-opioid receptor agonists was found to stimulate the intake of saccharin and salt solutions in nondeprived rats. In the present study, we measured the ...
Chemical sequencing of disulfide-crosslinked oligodeoxyribonucleotides
(Elsevier, 1993-10)
Oligodeoxyribonucleotides containing a novel disulfide crosslink are shown to be amenable to chemical sequencing using standard sequencing reagents following reduction of the disulfide with DTT and selective alkylation of ...
Uptake of metal cations by fibroblasts in vitro
(John Wiley & Sons, Inc., 1993-02)
Atomic absorption spectroscopy was used to assess uptake of Ag +1 , Au +4 , Cd +2 , Cu +2 , In +3 , Ni +2 , Pd +2 , and Zn +2 by in vitro cultures of Balb/c 3T3 fibroblasts as a function of concentration of the cations ...
Multicolor FISH Mapping with Alu-PCR-Amplified YAC Clone DNA Determines the Order of Markers in the BRCA1 Region on Chromosome 17q12-q21
(Elsevier, 1993-09)
A gene designated BRCA1, implicated in the susceptibility to early-onset familial breast cancer, has recently been localized to chromosome 17q12-q21. To date, the order of DNA markers mapped within this region has been ...
Structural Heterogeneity of Caucasian N-Acetyltransferase at the NAT1 Gene Locus
(Elsevier, 1993-02-15)
The human N-acetylation polymorphism is a genetic trait phenotypically reflected by differences in N-acetyltransferase (NAT) activity with therapeutic agents (rapid and slow acetylation), but a genetic invariability in ...
Comparison of the adrenalytic activity of mitotane and a methylated homolog on normal adrenal cortex and adrenal cortical carcinoma
(Springer-Verlag, 1993-11)
Mitotane is an important adrenalytic drug for the treatment of adrenal cancer whose use is limited by toxicity. Reports from another laboratory indicated that a methylated homolog of Mitotane (Mitometh) tested in guinea ...
Order-disorder transitions at and segregation to (001) Ni-Pt surfaces
(Elsevier, 1993-04-20)
Order-disorder transitions at and segregation to the (001) surface of Ni-Pt alloys have been investigated by a recently developed free energy simulation method, where the atomic interactions are described using the embedded ...