Now showing items 5041-5050 of 5057
Earth Abundant Transition Metal Molecular Complexes for Water Splitting
(2024)
Further development and understanding of the chemistry of earth-abundant transition-metal molecular catalysts for water splitting will aid development of a sustainable hydrogen economy. If dihydrogen can be produced ...
Borane-Appended Ligand Design Strategies for Small Molecule Capture and Reactivity
(2024)
In nature, metalloenzymes act as the premier catalysts for small molecule activation and transformation. The high activity and selectivity of enzymatic processes are, in part, owed to the complex system of acidic residues ...
CryoEM Structure with ATP Synthase Enables Late-Stage Diversification of Cruentaren A
(Wiley Periodicals, Inc., 2023-05-22)
Cruentaren A is a natural product that exhibits potent antiproliferative activity against various cancer cell lines, yet its binding site within ATP synthase remained unknown, thus limiting the development of improved ...
Development of Microfluidic, Immunoassay, Liquid Chromatography, and Mass Spectrometry Methods for Analysis of Islet Cell Secretions
(2024)
Cell secretion is a fundamental and highly regulated process which can inform on health, disease, cellular function, and cell-cell communication when interrogated, though this is analytically challenging. Instrumentation ...
Designing Chemical- and Light-Activated Protein Switches for Regulating Peptide Functions
(2023)
Peptides serve important biological functions including neuromodulation, hormonal regulation, cell signaling, protein localization, and enzyme inhibition. The ability to modulate peptide functions with precision is invaluable ...
Advancing Quantitative DNA Biomarker Detection through Single Molecule Fluorescence Kinetic Fingerprinting
(2024)
DNA (deoxyribonucleic acid), as the primary genetic material in eukaryotic organisms, is one of the major biomarkers for biological processes, pathological processes and drug responses in clinical diagnostics and prognostics. ...
Electrochemical Oxidation of Bio-derivable Alcohols Using Inorganic Materials and Mediators
(2024)
Upcoming depletion of non-renewable fossil fuels provides an urgent prompt for reshaping the current structure of both direct energy sources and processing for industrial chemicals. Biorefinery hints an alternative pathway ...
The Development of Unorthodox Amine-Acid Coupling Reactions and Their Applications Towards Complex Molecules for a Systems Approach to Chemistry
(2024)
A molecule’s properties are intimately linked to its medicinal function, yet there is a gap in our understanding of the interaction between properties and chemical synthesis. The most popular reaction in medicinal chemistry, ...
Computational Investigations of Conformational Effects in Organometallic Polymerization Catalysts
(2023)
Computational chemistry is a powerful tool for increasing understanding of known chemistry, discovering new reaction mechanisms, and improving catalyst properties and design. It can provide physical insights that would be ...
Electronic Modulation of Semimetallic Electrode for 2D van der Waals Devices
(Wiley Periodicals, Inc., 2023-05)