Now showing items 5051-5057 of 5057
Diagnostic and Prognostic Profiling of Infectious Diseases Through Multiplexed Protein Assays
(2024)
Laboratory-based biomarkers can indicate that normal biologic functions, pathogenic processes, or immunologic responses have occurred. Diagnostic biomarkers are used diagnose patients with a specific disease or condition, ...
Developing Methods for Reaction Informatics and Automation
(2024)
As the field of organic synthesis enters the digital age, an unprecedented number of tools are opened up for analyzing, planning and executing chemical reactions. This thesis will describe the development of two methods ...
Molecular Dynamics Simulations Guide Chimeragenesis and Engineered Control of Chemoselectivity in Diketopiperazine Dimerases
(Wiley Periodicals, Inc., 2023-05-08)
In the biosynthesis of the tryptophan-linked dimeric diketopiperazines (DKPs), cytochromes P450 selectively couple DKP monomers to generate a variety of intricate and isomeric frameworks. To determine the molecular basis ...
Mechanistic Studies on the Prenylated- Flavin-Dependent Phenazine-1-Carboxylic Acid Decarboxylase
(2024)
Decarboxylases are chemically versatile enzymes capable of manipulating C–C bonds by reversibly converting carboxylic acids to their corresponding hydrocarbons. Thus, they are being considered as viable biocatalysts for ...
Leveraging the Persistent Radical Effect in the Synthesis of Resveratrol Natural Products
(2024)
The use of radicals as intermediates in total synthesis has evolved since their initial use in the latter half of the twentieth century. Our group has long been interested in harnessing the power of radicals in the total ...
Lower Energy Excitation of Water Soluble Near-Infrared Emitting Mixed-Ligand Metallacrowns
(Wiley Periodicals, Inc.Elsevier Science B. V., 2023-05-22)
By combining advantages of two series of lanthanide(III)/zinc(II) metallacrowns (MCs) assembled using pyrazine- (pyzHA2−) and quinoxaline- (quinoHA2−) hydroximate building blocks ligands, we created here water-soluble ...
Progress in Predicting Ionic Cocrystal Formation: The Case of Ammonium Nitrate
(Wiley Periodicals, Inc., 2023-05-11)
In contrast to the mature predictive frameworks applied to neutral cocrystals, ionic cocrystals, those including an ion pair, are difficult to design. Furthermore, they are generally excluded categorically from studies ...