Now showing items 181-184 of 184
Identifying influential individuals in linkage analysis: Application to a quantitative trait locus detected in the COGA data
(Wiley Subscription Services, Inc., A Wiley Company, 1999)
Once linkage is detected to a quantitative trait locus (QTL), the next step towards localizing the gene involved may be to identify those families, or individuals, in whom the putative mutations are segregating. In this ...
Dinucleotide polymorphism at the DXS1178 locus is tightly linked to PGK1 at Xq13
(Springer-Verlag, 1995-04)
A polymorphic CA repeat (locus name DXS1178 ) was isolated from a 1-megabase YAC (OTCC) containing the OTC gene, located at Xp21.1. However, amplification in human-rodent hybrid cells and segregation analysis in three CEPH ...
cDNA sequence and genomic structure of EVI2B, a gene lying within an intron of the neurofibromatosis type 1 gene
(Elsevier, 1991-03)
The gene responsible for neurofibromatosis type 1 (NF1), one of the more common inherited human disorders, was identified recently, and segments of it were cloned. Two translocation breakpoints that interrupt the NF1 gene ...
Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization
(Springer-Verlag, 1992-07)
Two highly conserved forms of cellular retinoic acid binding protein (CRABP-I and CRABP-II) have been described, and one, CRABP-II, is highly expressed in human skin. We have utilized a 10-kb fragment containing the human ...